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020 _a9781441999207
_9978-1-4419-9920-7
024 7 _a10.1007/978-1-4419-9920-7
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aKompella, Uday B.
_eeditor.
245 1 0 _aDrug Product Development for the Back of the Eye
_h[electronic resource] /
_cedited by Uday B. Kompella, Henry F. Edelhauser.
264 1 _aBoston, MA :
_bSpringer US,
_c2011.
300 _aXII, 592 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAAPS Advances in the Pharmaceutical Sciences Series,
_x2210-7371 ;
_v2
505 0 _aSelection of Drug Delivery Approaches for the Back of the Eye: Opportunities and Unmet Needs -- Microdialysis for Vitreal Pharmacokinetics -- Fluorophotometry for Pharmacokinetic Assessment -- Systemic Route for Retinal Drug Delivery: Role of the Blood-Retinal Barrier -- Topical Drug Delivery to the Back of the Eye -- Principles of Retinal Drug Delivery from Within the Vitreous -- Transscleral Drug Delivery -- Suprachoroidal and Intrascleral Drug Delivery -- Advances in Biodegradable Ocular Drug Delivery Systems -- Microparticles as Drug Delivery Systems for the Back of the Eye -- Nanotechnology and Nanoparticles -- Hydrogels for Ocular Posterior Segment Drug Delivery -- Refillable Devices for Therapy of Ophthalmic Diseases -- Targeted Drug Delivery to the Eye Enabled by Microneedles -- Ocular Iontophoresis -- Drug and Gene Therapy Mediated by Physical Methods -- Protein Drug Delivery and Formulation Development -- Drug Suspension Development for the Back of the Eye -- Regulatory Considerations in Product Development for Back of the Eye -- Clinical Endpoints for Back of the Eye Diseases -- Druggable Targets and Therapeutic Agents for Disorders of the Back of the Eye -- Development of Bile Acids as Anti-Apoptotic and Neuroprotective Agents in Treatment of Ocular Disease.
520 _aThis comprehensive volume discusses approaches for a systematic selection of delivery systems for various classes of therapeutic agents including small molecule, protein, and nucleic acid drugs. Specific topics covered in this book include: Solution, suspension, gel, nanoparticle, microparticle, and implant dosage forms Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Clinical endpoints and regulatory path to drug product development Emerging and existing drugs and drug targets   Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering.   Uday B. Kompella, Ph.D., Professor of Pharmaceutical Sciences & Ophthalmology, University of Colorado, developed functionalized nanoparticles, nanoporous microparticles, microparticles, injectable implants, dendrimers, liposomes, and in situ forming gels for the eye. He is a Fellow of the American Association of Pharmaceutical Scientists (2005) and the Association for Research in Vision and Ophthalmology (2010). He received Distinguished Scientist (2006) Award from the University of Nebraska.   Henry F. Edelhauser, Ph.D., Professor of Ophthalmology, Emory University, made pioneering contributions towards transcorneal, transscleral, and suprachoroidal drug delivery to the eye. He is a recipient of the Castroviejo Medal and the Alcon Research Award (1999), American Academy of Ophthalmology Senior Achievement Award (2000), and the Procter Medal (2005) for his outstanding ophthalmic translational research. He served as the president of the Association for Research in Vision and Ophthalmology (1990-91).
650 0 _aMedicine.
650 0 _aToxicology.
650 0 _aPharmaceutical technology.
650 0 _aOphthalmology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aOphthalmology.
650 2 4 _aPharmaceutical Sciences/Technology.
700 1 _aEdelhauser, Henry F.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441999191
830 0 _aAAPS Advances in the Pharmaceutical Sciences Series,
_x2210-7371 ;
_v2
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-9920-7
912 _aZDB-2-SBL
999 _c106155
_d106155