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001 978-1-4419-9495-0
003 DE-He213
005 20140220083729.0
007 cr nn 008mamaa
008 110527s2011 xxu| s |||| 0|eng d
020 _a9781441994950
_9978-1-4419-9495-0
024 7 _a10.1007/978-1-4419-9495-0
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
100 1 _aChiappelli, Francesco.
_eauthor.
245 1 0 _aOsteoimmunopathology
_h[electronic resource] :
_bEvidence-Based Perspectives from Molecular Biology to Systems Biology /
_cby Francesco Chiappelli.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2011.
300 _aXII, 137p. 40 illus., 3 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPart 1: Fundamentals -- Osteoimmunology: Introduction to a new field -- Immunobiology -- Bone metabolism -- The Osteoimmune system: RANK-RANKL (et all) -- Part II: Clinical & Translational Research -- Clinical & Translational research – Fundamental Principles -- Evidence-Based Research in Osteoimmunology -- Evidence-Based Clinical Osteoimmune Practice -- Special population * Problems-Based Osteoimmunology -- Part III: Challenges for the Future -- Biomarkers -- Epigenetic and Chromatin Regulation in Osteoimmune Regulation -- Stem Cells Niches and Osteoimmune Microenvironments -- Techniques & Protocols.-.
520 _aOsteoimmunology pertains to the study of the relationship between the bones, particularly the bone marrow, and the immune system.   This monograph pursues the best available evidence, by means of research synthesis, for the characterization of the physiological relevance and pathological implications of the inter-connectedness between the skeletal and the immune system.  Research will be discussed that highlights the associated role of the circulatory, nervous and endocrine systems, as well as proteomic and genomic pathways and signatures. Emphasis is given that domain of medicine that relates to the oral cavity, its diseases and their systemic sequelae. This monograph arises from observations that have suggested that the skeletal system and the immune system are intimately intertwined. Chronic inflammatory reactions subsequent to an excessive immune reaction can damage the bones, as in rheumatoid arthritis (RA), osteoporosis, patients seropositive for the human immunodeficiency virus (HIV)-1 and with signs and sympotoms of the acquired immune deficiency syndrome (AIDS), and bone cancer. Bones – in particular the bone marrow – are one of the primary locations in which cells of the immune system mature. In brief, this monograph begins to answer a range of  questions, such as, what is osteoimmunology all about?, does the immune system and its components affect bone development?, how do stress hormones impact upon the pathophysiology of bone-immune interactions?, can the scientific process of research synthesis, obtain the best available evidence for treatment of diseases involving the bone-immune entity (i.e., osteoimmunopathologies) means of evidence-based clinical decision-making directed at the treatment of osteoimmune pathologies?
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aToxicology.
650 0 _aBiotechnology.
650 0 _aEmerging infectious diseases.
650 0 _aPathology.
650 0 _aMicrobiology.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aMicrobiology.
650 2 4 _aInfectious Diseases.
650 2 4 _aBiotechnology.
650 2 4 _aPathology.
650 2 4 _aPharmacology/Toxicology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441994943
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-9495-0
912 _aZDB-2-SBL
999 _c106065
_d106065