000			04721nam a22005175i 4500
001			978-1-4419-8831-7
003			DE-He213
005			20140220083728.0
007			cr nn 008mamaa
008			110503s2011 xxu| s |||| 0|eng d
020			_a9781441988317 _9978-1-4419-8831-7
024	7		_a10.1007/978-1-4419-8831-7 _2doi
050		4	_aQD95-96
072		7	_aPNFS _2bicssc
072		7	_aSCI078000 _2bisacsh
082	0	4	_a543.2-543.8 _223
100	1		_aCarlton, Robert Allen. _eauthor.
245	1	0	_aPharmaceutical Microscopy _h[electronic resource] / _cby Robert Allen Carlton.
264		1	_aNew York, NY : _bSpringer New York, _c2011.
300			_aXIV, 321p. 139 illus., 102 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aChapter 1: Introduction -- METHODS AND TECHNIQUES Chapter 2: Polarized Light Microscopy: Theory of PLM -- Polarized Light -- Optical Crystallography -- Types of Instruments -- Köhler Illumination -- Chapter 3: Thermal Microscopy -- Introduction -- Instruments and Methods -- Calibration -- Observations -- Exercises -- Chapter 4: SEM and EDS: Scanning Electron Microscopy -- Energy Dispersive X-ray Spectrometry -- Exercises -- Chapter 5: Microspectroscopy: Theory -- Infrared Microspectroscopy -- Raman Microspectroscopy -- Chemical Imaging -- Exercises -- Chapter 6: Other Types of Microscopy: Confocal Microscopy -- Atomic Force Microscopy -- Transmission Electron Microscopy -- DIC -- Phase contrast -- Dispersion staining -- Flourescence -- Freeze dry microscopy -- Chapter 7: Image Analysis: Digital Image Analysis -- Statistical Analysis -- Exercises (using ImageJ or Joys program) -- APPLICATIONS Chapter 8: Polymorphism: Theory -- Early Stage Development Studies -- Late Stage Development Studies -- Exercises -- Chapter 9: Size and Shape Analysis: Theory -- Sampling -- Comparison with other Techniques -- Automation -- Validation -- Exercises -- Chapter 10: Contaminant Analysis: General Approach -- Examples -- Exercises -- Chapter 11: Conclusion -- Chapter 12: References and Bibliography.-.
520			_aMicroscopy plays an integral role in the research and development of new medicines. Pharmaceutical Microscopy describes a wide variety of  techniques together with numerous practical  applications of importance in drug development. The first section  presents general methods and applications with an emphasis on the physical science aspects. Techniques covered include optical crystallography, thermal microscopy, scanning electron microscopy, energy dispersive x-ray spectrometry, microspectroscopy (infrared and Raman), and particle size and shape by image analysis. The second section presents applications of these techniques to specific topics of pharmaceutical interest, including studies of polymorphism, particle size and shape analysis, and contaminant identification.  Pharmaceutical Microscopy is designed for those scientists who must use these techniques to solve pharmaceutical problems but do not need to become expert microscopists.  Consequently, each section has exercises designed to teach the reader how to use and apply the techniques in the book.  Although the focus is on pharmaceutical development, workers in other fields such as food science and organic chemistry will also benefit from the discussion of techniques and the exercises. Provides comprehensive coverage of key microscopy techniques used in pharmaceutical development Helps the reader to solve specific problems in pharmaceutical quality assurance Oriented and designed for pharmaceutical scientists who need to use microscopy but are not expert microscopists Includes a large number of practical exercises to give the reader hands-on experience with the techniques Written by an author with 21 years of experience in the pharmaceutical industry
650		0	_aChemistry.
650		0	_aPharmaceutical technology.
650		0	_aSpectroscopy.
650		0	_aFood science.
650		0	_aMicroscopy.
650		0	_aSurfaces (Physics).
650	1	4	_aChemistry.
650	2	4	_aSpectroscopy/Spectrometry.
650	2	4	_aPharmaceutical Sciences/Technology.
650	2	4	_aCharacterization and Evaluation of Materials.
650	2	4	_aFood Science.
650	2	4	_aBiological Microscopy.
650	2	4	_aSpectroscopy and Microscopy.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441988300
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4419-8831-7
912			_aZDB-2-CMS
999			_c106014 _d106014