000 03073nam a22004455i 4500
001 978-1-4419-8417-3
003 DE-He213
005 20140220083728.0
007 cr nn 008mamaa
008 110504s2011 xxu| s |||| 0|eng d
020 _a9781441984173
_9978-1-4419-8417-3
024 7 _a10.1007/978-1-4419-8417-3
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aJackman, Ann L.
_eeditor.
245 1 0 _aTargeted Drug Strategies for Cancer and Inflammation
_h[electronic resource] /
_cedited by Ann L. Jackman, Christopher P. Leamon.
264 1 _aBoston, MA :
_bSpringer US,
_c2011.
300 _aXI, 254 p. 69 illus., 22 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aBiological Role, Properties and Therapeutic Applications of the Reduced Folate Carrier (RFC-SLC19A1) and the Proton-Coupled Folate Transporter (PCFT-SLC46A1) -- Folate Receptors and Therapeutic Applications -- Hormonal Control of Folate Receptor Genes -- Folate Receptor Targeted Radionuclide Imaging Agents -- Folate receptor targeted thymidylate synthase inhibitors -- Discovery of novel antifolate inhibitors of de novo purine nucleotide biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry -- Folate-receptor targeted cancer chemotherapy -- Anti-FR antibody generation and engineering: development of new therapeutic tools -- Folate Receptor Positive Macrophages: Cellular Targets for Imaging and Therapy of Inflammatory and Autoimmune Diseases -- Targeting Activated Macrophages via a Functional Folate Receptor for Potential Treatment of Autoimmune/Inflammatory Disorders.-.
520 _aThe discoveries highlighted in this book parallel the emergence of innovative “molecular targeted” small molecules and monoclonal antibodies, i.e. agents that target proteins within highly activated signal transduction pathways that control proliferation.  Many of the tumor-targeted strategies described within cross the boundaries between what’s considered to be “molecular targeted” versus conventional systemic therapy.  However, the main theme of this volume is the folate receptor (FR), with much of the content focused on its basic biology and regulation as well as its exploitation for targeted therapy and diagnostic imaging.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aToxicology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aPharmacology/Toxicology.
700 1 _aLeamon, Christopher P.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441984166
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-8417-3
912 _aZDB-2-SBL
999 _c105992
_d105992