000 03976nam a22004575i 4500
001 978-1-4419-8023-6
003 DE-He213
005 20140220083726.0
007 cr nn 008mamaa
008 110124s2011 xxu| s |||| 0|eng d
020 _a9781441980236
_9978-1-4419-8023-6
024 7 _a10.1007/978-1-4419-8023-6
_2doi
050 4 _aRC254-282
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a616.994
_223
100 1 _aGoss, Kathleen H.
_eeditor.
245 1 0 _aTargeting the Wnt Pathway in Cancer
_h[electronic resource] /
_cedited by Kathleen H. Goss, Michael Kahn.
264 1 _aNew York, NY :
_bSpringer New York,
_c2011.
300 _aXI, 241p. 17 illus., 13 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aAn Introduction to Wnt Signaling.- Regulation of Wnt Secretion and Distribution -- Wnt Signaling in Stem Cells -- Crosstalk of the Wnt Signaling Pathway -- Dysregulation of the WNT Pathway in Solid Tumors.- WNT/b-catenin Signaling in Leukemia -- Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer -- Targeting Wnt Signalling in Cancer -- Inhibiting the Wnt Signaling Pathway with Small Molecules.- Targeting of Wnt Signaling Inside the Nucleus.-.
520 _aThe Wnt pathway is an evolutionarily conserved signaling network that is critical for mammalian development and adult tissue maintenance, and, importantly, hyperactivated in most human cancers. Almost two decades of study has confirmed that Wnt signaling is necessary and sufficient for cancer pathogenesis in multiple in vitro and in vivo models systems, suggesting that the pathway represents an attractive therapeutic target.  Recent efforts have focused on innovative strategies to antagonize Wnt signaling at various levels of the pathway – from attenuating the extracellular signaling through the Wnt receptors to modulating the catenin destruction complex to blocking catenin-mediated transcription. Many of these approaches have been largely successful in preclinical validation studies and have been met with considerable enthusiasm to move forward into clinical trials. In this book, we highlight the recent advances in our understanding of the complexity of the Wnt pathway, particularly its intricate regulation and cross-talk with other key signal transduction pathways in normal and tumor cells. As a way to comprehend the role of Wnt pathway activation in tumor initiation and progression, we discuss the importance of Wnt signaling in embryonic and tissue development and stem cell maintenance and self-renewal. The evidence for aberrant Wnt pathway activation in human solid and hematopoietic cancers, as well as a few of the genetic mouse models that mimic the Wnt pathway deregulation observed in some of these tumor types, is reviewed. Lastly, we summarize the current status of the development of Wnt pathway inhibitors, their efficacy in preclinical models and their potential as therapeutic agents for cancer. It is an exciting time in the Wnt signaling field – one that represents a key crossroad between dissecting the molecular details of the pathway and translating that work into promising targeted tumor therapies – that is likely to profoundly impact this research area for years to come.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aToxicology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aOncology.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aCancer Research.
700 1 _aKahn, Michael.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441980229
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-8023-6
912 _aZDB-2-SME
999 _c105915
_d105915