000 03726nam a22004935i 4500
001 978-1-4419-7835-6
003 DE-He213
005 20140220083725.0
007 cr nn 008mamaa
008 110105s2011 xxu| s |||| 0|eng d
020 _a9781441978356
_9978-1-4419-7835-6
024 7 _a10.1007/978-1-4419-7835-6
_2doi
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aPHVD
_2bicssc
072 7 _aSCI009000
_2bisacsh
082 0 4 _a571.4
_223
100 1 _aGerecht, Sharon.
_eeditor.
245 1 0 _aBiophysical Regulation of Vascular Differentiation and Assembly
_h[electronic resource] /
_cedited by Sharon Gerecht.
250 _a1.
264 1 _aNew York, NY :
_bSpringer New York,
_c2011.
300 _aXIV, 254 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aBiological and Medical Physics, Biomedical Engineering,
_x1618-7210
505 0 _aPreface -- Embryonic and Adult Stem Cells in Vasculogenesis and Angiogenesis -- Extracellular Matrix and Matrix Metalloproteinase in Vascular Morphogenesis -- Scaffolding for Three-Dimensional Embryonic Vasculogenesis -- Matrix Viscoelasticity and Remodeling During 3D Vascular Assembly -- Biomechanical Properties of Implanted Scaffolds Affect Human Blood Vessel Formation From Circulating Endothelial Colony Forming Cells -- Oxygen Regulation of Adult Angiogenesis -- Hypoxia During Embryonic Vascular Development and Differentiation -- Three-Dimensional Regulation During Cancerous Angiogenesis -- Microfluidics to Control Shear and Oxygen Flow for Vascular Differentiation -- Cyclic Strain and Surface Shape for Engineered Vasculature Constructs -- Matrix Topography and Viscoelasticity Guide Vascular Assembly.
520 _aThe ability to grow stem cells in the laboratory and to guide their maturation to functional cells allows us to study the underlying mechanisms that govern vasculature differentiation and assembly in health and disease. Accumulating evidence suggests that early stages of vascular growth are exquisitely tuned by biophysical cues from the microenvironment, yet the scientific understanding of such cellular environments is still in its infancy. Comprehending these processes sufficiently to manipulate them would pave the way to controlling blood vessel growth in therapeutic applications. This book assembles the works and views of experts from various disciplines to provide a unique perspective on how different aspects of its microenvironment regulate the differentiation and assembly of the vasculature. In particular, it describes recent efforts to exploit modern engineering techniques to study and manipulate various biophysical cues. Biophysical Regulation of Vascular Differentiation and Assembly provides an interdisciplinary view of vasculature regulation by various biophysical cues and presents recent advances in measuring and controlling such parameters. This book will be of interest to biologists, biophysicists and engineers who work with vascular differentiation and assembly.
650 0 _aPhysics.
650 0 _aStem cells.
650 0 _aBiomedical engineering.
650 1 4 _aPhysics.
650 2 4 _aBiophysics and Biological Physics.
650 2 4 _aBiomedical Engineering.
650 2 4 _aStem Cells.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441978349
830 0 _aBiological and Medical Physics, Biomedical Engineering,
_x1618-7210
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-7835-6
912 _aZDB-2-PHA
999 _c105871
_d105871