000			03646nam a22004935i 4500
001			978-1-4419-7725-0
003			DE-He213
005			20140220083725.0
007			cr nn 008mamaa
008			110504s2011 xxu| s |||| 0|eng d
020			_a9781441977250 _9978-1-4419-7725-0
024	7		_a10.1007/978-1-4419-7725-0 _2doi
050		4	_aQR180-189.5
072		7	_aMJCM _2bicssc
072		7	_aMED044000 _2bisacsh
082	0	4	_a616.079 _223
100	1		_aMolina-París, Carmen. _eeditor.
245	1	0	_aMathematical Models and Immune Cell Biology _h[electronic resource] / _cedited by Carmen Molina-París, Grant Lythe.
264		1	_aNew York, NY : _bSpringer New York, _c2011.
300			_aXVI, 407p. 48 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aPreface -- Thymocyte development -- A review of mathematical models for T cell receptor triggering and antigen discrimination -- Dynamic tuning of T cell receptor specificity by co-receptors and costimulation -- T cell activation and function: role of signal strength -- The cyton model for lymphocyte proliferation and differentiation -- Modeling itravital two-photon data of lymphocyte migration and interaction -- Modeling lymphocyte dynamics in vivo -- Continuous-time birth and death processes: diversity maintenance of naïve T cells in the periphery -- Multivariate competition processes: a model for two competing T cell clonotypes -- Stochastic modeling of T Cell homeostasis for two competing clonotypes via the master equation -- Dendritic cell migration in the intestinal tract -- Reassessing germinal center reaction concepts -- B cell strategies of Ag recognition in a stratified immune system -- Dynamics of Peripheral regulatory and effector T cells competing for antigen presenting cells -- Mathematical models of the role of IL-2 in the interactions between helper and regulstory CD4+ T cells -- A Physicist’s approach to immunology -- Timescales of the adaptive immune response -- Using mathematical models to explore the role of cytoxic T lymphocytes in HIV infection -- Viral immunity and persistence -- Index.
520			_aMathematical immunology is in a period of rapid expansion and excitement. At recent meetings, a common language and research direction has emerged amongst a world-class group of scientists and mathematicians. Mathematical Models and Immune Cell Biology aims to communicate these new ideas to a wider audience. The reader will be exposed to a variety of tools and methods that go hand-in-hand with the immunological processes being modeled. This volume contains chapters, written by immunologists and mathematicians, on thymocytes, on T cell interactions, activation, proliferation and homeostasis, as well as on dendritic cells, B cells and germinal centers. Chapters are devoted to measurement and imaging methods and to HIV and viral infections.
650		0	_aMedicine.
650		0	_aImmunology.
650		0	_aBioinformatics.
650		0	_aCell receptors.
650		0	_aBiological models.
650	1	4	_aBiomedicine.
650	2	4	_aImmunology.
650	2	4	_aSystems Biology.
650	2	4	_aComputational Biology/Bioinformatics.
650	2	4	_aReceptors.
700	1		_aLythe, Grant. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441977243
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4419-7725-0
912			_aZDB-2-SBL
999			_c105839 _d105839