000			04292nam a22005775i 4500
001			978-1-4419-6956-9
003			DE-He213
005			20140220083721.0
007			cr nn 008mamaa
008			110301s2011 xxu| s |||| 0|eng d
020			_a9781441969569 _9978-1-4419-6956-9
024	7		_a10.1007/978-1-4419-6956-9 _2doi
050		4	_aQH301-705
072		7	_aPSA _2bicssc
072		7	_aSCI086000 _2bisacsh
072		7	_aSCI064000 _2bisacsh
082	0	4	_a570 _223
100	1		_aBooß-Bavnbek, Bernhelm. _eeditor.
245	1	0	_aBetaSys _h[electronic resource] : _bSystems Biology of Regulated Exocytosis in Pancreatic ß-Cells / _cedited by Bernhelm Booß-Bavnbek, Beate Klösgen, Jesper Larsen, Flemming Pociot, Erik Renström.
250			_a1.
264		1	_aNew York, NY : _bSpringer New York, _c2011.
300			_aXX, 556 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aSystems Biology ; _v2
505	0		_aPreface -- Systems biology of β-cells - revisited -- Established facts and open questions of the focused systems analysis of regulated exocytosis in β-cells – a background for a focused systems analysis approach -- Mitochondria and metabolic signals in β-cells -- β-cell ontogenesis and the insulin production apparatus -- The role of the cytoskeleton in transport and release of the insulin-containing granules by pancreatic β-cells -- The mathematical microscope making the inaccessible accessible -- Magnetic resonance imaging of pancreatic β-cells -- Mapping the β-cell in 3D at the nanoscale using novel cellular electron tomography and computational approaches -- In vivo applications of inorganic nanoparticles -- Cell cultivation and sensor-based assays for dynamic measurements of cell vitality: basic concepts -- Bioimpedance spectroscopy -- DNA variations, impaired insulin secretion and type-2 diabetes -- Genetically programmed defects in β-cell function -- Proteomic analysis of the pancreatic islet β-cell secretory granule: current understanding and future opportunities -- Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin) - a role in the pathogenesis of type-2 diabetes -- Present state of islet transplantation for type-1 diabetes patients -- Predictive protein networks and identification of drugable targets in the β-cell -- Nanotoxicity -- From silicon cell to silicon human -- Probing cellular dynamics with mesoscopic simulations -- What drives calcium oscillations in β-cells? new tasks for cyclic analysis -- Whole-body and cellular models of glucose-stimulated insulin secretion -- Geometric and electromagnetic aspects of fusion pore making -- Index.
520			_aThe insulin secreting β-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological advances that make simultaneous detection of thousands of biological variables possible; at a substantial variety of mathematical models and numerical simulations that aim to explain major aspects of the β-cell function; and at the challenge to formulate a comprehensive and robust model of the main networks of the underlying biochemical and physical processes for diagnostic and therapeutic use.
650		0	_aLife sciences.
650		0	_aHuman genetics.
650		0	_aDiabetes.
650		0	_aBioinformatics.
650		0	_aBiological models.
650	1	4	_aLife Sciences.
650	2	4	_aSystems Biology.
650	2	4	_aHuman Genetics.
650	2	4	_aBioinformatics.
650	2	4	_aDiabetes.
700	1		_aKlösgen, Beate. _eeditor.
700	1		_aLarsen, Jesper. _eeditor.
700	1		_aPociot, Flemming. _eeditor.
700	1		_aRenström, Erik. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441969552
830		0	_aSystems Biology ; _v2
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4419-6956-9
912			_aZDB-2-SBL
999			_c105663 _d105663