000 05078nam a22005415i 4500
001 978-1-4419-6857-9
003 DE-He213
005 20140220083721.0
007 cr nn 008mamaa
008 110801s2011 xxu| s |||| 0|eng d
020 _a9781441968579
_9978-1-4419-6857-9
024 7 _a10.1007/978-1-4419-6857-9
_2doi
050 4 _aRG133.5
072 7 _aMFKC
_2bicssc
072 7 _aHEA039060
_2bisacsh
082 0 4 _a612.6
_223
100 1 _aZini, Armand.
_eeditor.
245 1 0 _aSperm Chromatin
_h[electronic resource] :
_bBiological and Clinical Applications in Male Infertility and Assisted Reproduction /
_cedited by Armand Zini, Ashok Agarwal.
264 1 _aNew York, NY :
_bSpringer New York,
_c2011.
300 _aXXII, 512p. 77 illus., 48 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aSperm Chromatin: An Overview -- Spermatogenesis: An Overview -- Sperm Nucleoproteins -- The Relationship Between Chromatin Structure and DNA Damage in Mammalian Spermatozoa -- Chromosome Positioning in Spermatozoa -- Sperm Mitochondrial DNA -- The Sperm Epigenome -- RNA Expression in Germ Cells During Spermatogenesis (Germ Cell Transcriptome) -- Sperm Chromatin Structure Assay (SCSA®): 30 Years’ Experience with the SCSA® -- Sperm Chromatin Dispersion Test: Technical Aspects and Clinical Applications -- Basic and Clinical Aspects of the Sperm Chromomycin A3 Assay -- Cytochemical Tests for Sperm Chromatin Maturity -- Acridine Orange Test for Assessment of Human Sperm DNA Integrity -- Laboratory Evaluation of Sperm Chromatin: TUNEL Assay -- The Basic and Clinical Aspects of the Sperm Comet Assay -- Assays Used in the Study of Sperm Nuclear Proteins -- Sperm Epigenetic Profile -- Clinical Significance of Sperm RNA -- Role of Oxidative Stress in the Etiology of Sperm DNA Damage -- Abortive Apoptosis and Sperm Chromatin Damage -- Spermiogenesis in Sperm Genetic Integrity -- Male Subfertility and Sperm Chromatin Damage -- Aging and Sperm DNA Damage -- Cancer in Males: Implications for Sperm Quality, Fertility, and Progeny Outcome -- Sperm Chromatin and Environmental Factors -- Effects of Male Accessory Gland Infection on Sperm Parameters -- The Impact of Sperm Processing and Cryopreservation on Sperm DNA Integrity -- Structure of Chromatin in Human Sperm Bound to Hyaluronic Acid: The Benefits of PICSI Dish Mediated Sperm Selection -- Electrophoretic Sperm Separation -- Antioxidants and Sperm DNA Damage -- Sperm Chromatin and ART (IUI, IVF, and ICSI) Pregnancy -- Sperm DNA Damage and Pregnancy Loss After IVF/ICSI -- Postnatal Effects of Sperm Chromatin Damage -- Evaluation of Chromatin and DNA Integrity in Testicular Sperm -- The Alkaline Comet Assay -- Sperm Chromatin Structure Assay (SCSA) -- Measurement of DNA Damage in Spermatozoa by TUNEL Assay -- Clinical Utility of Sperm DNA Integrity Tests.
520 _aSperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.
650 0 _aMedicine.
650 0 _aObstetrics.
650 0 _aEndocrinology.
650 0 _aReproductive Medicine.
650 0 _aUrology.
650 0 _aCytology.
650 0 _aDevelopmental biology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aReproductive Medicine.
650 2 4 _aEndocrinology.
650 2 4 _aDevelopmental Biology.
650 2 4 _aCell Biology.
650 2 4 _aObstetrics/Perinatology.
650 2 4 _aUrology/Andrology.
700 1 _aAgarwal, Ashok.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441917812
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-6857-9
912 _aZDB-2-SME
999 _c105647
_d105647