000 04332nam a22004935i 4500
001 978-1-4419-6382-6
003 DE-He213
005 20140220083720.0
007 cr nn 008mamaa
008 101013s2011 xxu| s |||| 0|eng d
020 _a9781441963826
_9978-1-4419-6382-6
024 7 _a10.1007/978-1-4419-6382-6
_2doi
050 4 _aQH345
050 4 _aQD415-436
072 7 _aPSB
_2bicssc
072 7 _aSCI007000
_2bisacsh
082 0 4 _a572
_223
100 1 _aVidal, Cecilio J.
_eeditor.
245 1 0 _aPost-Translational Modifications in Health and Disease
_h[electronic resource] /
_cedited by Cecilio J. Vidal.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2011.
300 _aXIV, 490 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aProtein Reviews ;
_v13
505 0 _aIsoprenoid Modifications -- GPI-Anchored Proteins in Health and Disease -- Protein Oxidation -- Involvement of S-Nitrosylation in Neurodegeneration -- Protein Glycosylation, and Congenital Disorders of Glycosylation -- Defective Glycosylation of Dystroglycan in Muscular Dystrophy and Cancer -- Protein kinase A: The Enzyme and Cyclic AMP Signaling -- The Protein Kinase C Family: Key Regulators Bridging Signaling Pathways in Skin and Tumor Epithelia -- Maintaining Energy Balance in Health and Disease: Role of AMP-activated Protein Kinase -- Protein Phosphatases in the Brain: Regulation, Function and Disease -- Covalent Protein Modification as a Mechanism for Dynamic Recruitment of Specific Interactors -- Regulation of Gene Expression by the Ubiquitin-Proteasome System and Implications for Neurological Disease -- Small Ubiquitin-like Modifiers and other Ubiquitin-like Proteins -- ER-associated Degradation and its Involvement in Human Disease: Insights from Yeast -- Regulation of Chromatin Structure and Transcription via Histone Modifications -- Chromatin: the Entry to and Exit from DNA Repair -- Poly(ADP-rybosyl)ation of Chromosomal Proteins: Epigenetic Regulation and Human Genomic Integrity in Health and Disease -- Post-translational Proteolytic Processing on Intracellular Proteins by Cathepsins and Cystatins -- Metalloproteases and Proteolytic Processing.
520 _aPost-translational modifications serve many different purposes in a wide variety of cellular processes,such as protein synthesis, folding, stability, the housing of prosthetic groups, vesicular trafficking,protein targeting to particular cell stores, exocytosis and endocytosis, the biogenesis of cell organelles and basal lamina. Signal transduction, with functional effects for enzyme regulation and metabolic control on the one hand, and gene expression, cell division, differentiation and apoptosis on the other, is also prominent. Post-translational Modifications in Health and Disease provides the reader with nineteen reviews that stimulate further investigations in the proteomic field - focusing on functional and pathological aspects of protein prenylation, the incorporation of glycosylphosphatidylinositol (GPI) moieties, oxidation, nitrosylation, glycosylation, and phosphorylation and dephosphorylation - with emphasis on their outcome for protein-protein interaction phenomena and down-stream effects. Additional chapters are devoted to protein ubiquitination, sumoylation and endoplasmic reticulum-associated degradation (ERAD), the influence of histone modification on gene expression and DNA repair, and proteolytic processing of intracellular and basal lamina proteins. This book will be of particular significance to researchers, clinicians, and students of biology, pharmacy and medicine.
650 0 _aLife sciences.
650 0 _aBiochemistry.
650 0 _aCytology.
650 1 4 _aLife Sciences.
650 2 4 _aBiochemistry, general.
650 2 4 _aAnimal Biochemistry.
650 2 4 _aMedical Biochemistry.
650 2 4 _aCell Biology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441963819
830 0 _aProtein Reviews ;
_v13
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-6382-6
912 _aZDB-2-SBL
999 _c105603
_d105603