000 03364nam a22005055i 4500
001 978-94-007-5291-7
003 DE-He213
005 20140220083348.0
007 cr nn 008mamaa
008 121230s2012 ne | s |||| 0|eng d
020 _a9789400752917
_9978-94-007-5291-7
024 7 _a10.1007/978-94-007-5291-7
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aPalmieri, Diane.
_eeditor.
245 1 0 _aCentral Nervous System Metastasis, the Biological Basis and Clinical Considerations
_h[electronic resource] /
_cedited by Diane Palmieri.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2012.
300 _aXI, 226 p. 32 illus., 27 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCancer Metastasis - Biology and Treatment,
_x1568-2102 ;
_v18
505 0 _aPreface -- List of Contributors -- 1 An Introduction to Brain Metastasis -- 2 The Molecular Biology of Brain Metastasis -- 3 The Brain Microenvironment -- 4 Vascular permeability within brain metastases -- 5 Imaging Experimental Brain Metastases -- 6 Possibilities of Targeted Therapies for Brain Metastasis -- 7  Surgery for Brain Metastasis -- 8  Is There A Role for Systemic Chemotherapy in the Treatment of Brain Metastases? -- 9  Radiation Therapy of CNS Metastases -- 10  Leptomeningeal Metastasis -- 11 Quality of Life in CNS Metastasis -- Index.
520 _aThis volume covers what is known regarding the natural history, basic biology, and clinical aspects, including imaging and treatment, of CNS metastasis. Three chapters cover the biology of the brain and brain metastases: molecular biology, includes what is known about specific genes/proteins involved in the process of metastasis and model systems to study brain metastasis; brain microenvironment, focuses on the resident cells of the microenvironment and their role in CNS metastasis; and the blood-brain barrier, includes a discussion of permeability with respect to brain metastases. A discussion of experimental imaging covers both the biology of brain metastasis from an imaging perspective and the use of imaging techniques to study brain metastases. The three clinical chapters discuss treatment options of surgery, chemotherapy, and radiation. The potential for novel targeted therapies is also addressed. Because of the uniqueness of the disease, leptomeningeal metastasis is discussed separately. The last chapter is devoted to quality of life issues associated with CNS metastasis.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aNeurosciences.
650 0 _aRadiology, Medical.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aNeurosciences.
650 2 4 _aOncology.
650 2 4 _aImaging / Radiology.
650 2 4 _aBiomedicine general.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400752900
830 0 _aCancer Metastasis - Biology and Treatment,
_x1568-2102 ;
_v18
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-5291-7
912 _aZDB-2-SBL
999 _c104854
_d104854