| 000 | 02667nam a22004575i 4500 | ||
|---|---|---|---|
| 001 | 978-94-007-5128-6 | ||
| 003 | DE-He213 | ||
| 005 | 20140220083348.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 121116s2012 ne | s |||| 0|eng d | ||
| 020 |
_a9789400751286 _9978-94-007-5128-6 |
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| 024 | 7 |
_a10.1007/978-94-007-5128-6 _2doi |
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| 050 | 4 | _aRS380 | |
| 050 | 4 | _aRS190-210 | |
| 072 | 7 |
_aTDCW _2bicssc |
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| 072 | 7 |
_aMED072000 _2bisacsh |
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| 082 | 0 | 4 |
_a615.19 _223 |
| 100 | 1 |
_aBarron, Niall. _eeditor. |
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| 245 | 1 | 0 |
_aMicroRNAs as Tools in Biopharmaceutical Production _h[electronic resource] / _cedited by Niall Barron. |
| 264 | 1 |
_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2012. |
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| 300 |
_aIX, 124 p. 9 illus., 6 illus. in color. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 520 | _aMicroRNAs are small, non-coding RNA molecules that interact with target mRNAs to modulate their translation. They are now recognized as widespread and critical regulators of gene expression in the cell. This book is aimed at both industry- and academic-based researchers in the Biopharmaceutical production space who wish to learn more about these fascinating molecules. It provides an overview of what is currently known about microRNAs including: · a description of their biogenesis and mode of action · how they can be detected and measured · methods for predicting their target genes · how we can manipulate their levels in the cell · what lessons can be learned from their behaviour in cancer cells Most importantly this volume addresses how microRNAs might be utilised in the bioprocess setting to: · gain new understanding of CHO cell biology · design microRNAs expression engineering strategies to influence cell characteristics such as proliferation rate or recombinant protein productivity · predict phenotypic outcomes in cell line development projects | ||
| 650 | 0 | _aMedicine. | |
| 650 | 0 | _aPharmaceutical technology. | |
| 650 | 0 | _aGenetic engineering. | |
| 650 | 0 | _aAnimal genetics. | |
| 650 | 1 | 4 | _aBiomedicine. |
| 650 | 2 | 4 | _aPharmaceutical Sciences/Technology. |
| 650 | 2 | 4 | _aGenetic Engineering. |
| 650 | 2 | 4 | _aAnimal Genetics and Genomics. |
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9789400751279 |
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-94-007-5128-6 |
| 912 | _aZDB-2-SBL | ||
| 999 |
_c104848 _d104848 |
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