000			02999nam a22004455i 4500
001			978-94-007-4936-8
003			DE-He213
005			20140220083347.0
007			cr nn 008mamaa
008			120930s2012 ne | s |||| 0|eng d
020			_a9789400749368 _9978-94-007-4936-8
024	7		_a10.1007/978-94-007-4936-8 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aRibatti, Domenico. _eauthor.
245	1	0	_aMorphofunctional Aspects of Tumor Microcirculation _h[electronic resource] / _cby Domenico Ribatti.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2012.
300			_aXI, 116 p. 27 illus., 23 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aList of abbreviations -- Introduction -- 1.1.Tumor endothelial cell features -- 1.2. Tumor pericytes -- 1.3. Tumor lymphatic vessels -- 2.1.Tumor angiogenesis -- 2.2.The role of inflammatory cells in tumor angiogenesis -- 2.3. Alternative mode of tumor vascular growth -- 2.4. The role of bone marrow stem cells in tumor angiogenesis --  3.1. Anti-angiogenic therapy -- 3.2. Metronomic chemotherapy -- 3.3.Combinatorial approach -- 3.4.Vascular targeting to tumor vasculature -- 3.5. Tumor vascular normalization -- 3.6. Drawbacks of anti-angiogenesis therapies -- References.
520			_aBlood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodelling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aCytology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aOncology.
650	2	4	_aCell Biology.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400749351
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-4936-8
912			_aZDB-2-SBL
999			_c104831 _d104831