000 03122nam a22005055i 4500
001 978-94-007-4765-4
003 DE-He213
005 20140220083347.0
007 cr nn 008mamaa
008 121116s2012 ne | s |||| 0|eng d
020 _a9789400747654
_9978-94-007-4765-4
024 7 _a10.1007/978-94-007-4765-4
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aDupré, Denis J.
_eeditor.
245 1 0 _aGPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity
_h[electronic resource] /
_cedited by Denis J. Dupré, Terence E. Hébert, Ralf Jockers.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2012.
300 _aVIII, 299 p. 43 illus., 36 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSubcellular Biochemistry,
_x0306-0225 ;
_v63
520 _aThis book provides a broad survey of various topics pertaining to G protein coupled receptor (GPCR) assembly into specific signalling complexes, and the regulation of the events leading to this assembly. Throughout this book, we focus on one main area: GPCRs are involved in highly efficient and specific activation of signalling pathways; how are these signalling complexes assembled to generate such specificity? To address this issue, we need to understand how receptors and their signalling partners are synthesized, folded correctly and assembled in order to generate functional complexes. The effects of oligomerization on specificity and efficacy of signal transduction are also discussed. Once receptor complexes are assembled, how are they targeted to different intracellular sites and what controls the trafficking of GPCR signalling complexes? Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCR signalling complexes; how can we manipulate these systems to normalize them functionally?  Therefore, the topics to be covered in this book are: 1) Molecular chaperones involved in regulating (quality control) of GPCR synthesis; 2) Assembly of signalling complexes, or subunits of the complex and their organization; 3) GPCR oligomerization; 4) GPCR trafficking; 5) Problems of trafficking: pharmacological chaperones to the rescue.
650 0 _aMedicine.
650 0 _aToxicology.
650 0 _aBiochemistry.
650 0 _aCell receptors.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aReceptors.
650 2 4 _aMedical Biochemistry.
700 1 _aHébert, Terence E.
_eeditor.
700 1 _aJockers, Ralf.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400747647
830 0 _aSubcellular Biochemistry,
_x0306-0225 ;
_v63
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-4765-4
912 _aZDB-2-SBL
999 _c104812
_d104812