000 03246nam a22005415i 4500
001 978-94-007-4315-1
003 DE-He213
005 20140220083346.0
007 cr nn 008mamaa
008 120618s2012 ne | s |||| 0|eng d
020 _a9789400743151
_9978-94-007-4315-1
024 7 _a10.1007/978-94-007-4315-1
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aToman, Rudolf.
_eeditor.
245 1 0 _aCoxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium
_h[electronic resource] /
_cedited by Rudolf Toman, Robert A. Heinzen, James E. Samuel, Jean-Louis Mege.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2012.
300 _aXIV, 406 p. 36 illus., 21 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v984
520 _aOver 20 years have elapsed since publication of the seminal two volume series entitled Q Fever: The Biology of Coxiella burnetii (edited by J. C. Williams and H. A. Thompson) and Q fever: The Disease (edited by T. J. Marrie) that described the current state of Coxiella burnetii research. The ensuing years have brought the post-genomic era and accompanying technologies that have catalyzed major advances in the field, including milestones discoveries of genetic transformation and host cell-free growth of this former obligate intracellular bacterium. Understanding how the bacterium resists the degradative functions of vacuole, and the host cell functions coopted for successful parasitism, are central to understanding Q fever pathogenesis. Recent achievements in glycomics and proteomics are guiding development of enhanced detection schemes for the bacterium in addition to shedding light on the host immune response to the pathogen.   The book covers the current state-of-the-art knowledge in the selected fields of C. burnetii/Q fever research. Coxiella has matured from a niche organism, investigated by a handful of laboratories worldwide, to a model system to study macrophage parasitism, developmental biology, host-pathogen interactions, and immune evasion/modulation.
650 0 _aMedicine.
650 0 _aGenetic engineering.
650 0 _aEmerging infectious diseases.
650 0 _aBioinformatics.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aCell Biology.
650 2 4 _aGenetic Engineering.
650 2 4 _aInfectious Diseases.
650 2 4 _aComputational Biology/Bioinformatics.
700 1 _aHeinzen, Robert A.
_eeditor.
700 1 _aSamuel, James E.
_eeditor.
700 1 _aMege, Jean-Louis.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400743144
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v984
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-4315-1
912 _aZDB-2-SBL
999 _c104755
_d104755