000			03221nam a22005055i 4500
001			978-94-007-4213-0
003			DE-He213
005			20140220083346.0
007			cr nn 008mamaa
008			120613s2012 ne | s |||| 0|eng d
020			_a9789400742130 _9978-94-007-4213-0
024	7		_a10.1007/978-94-007-4213-0 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aHayat, M.A. _eeditor.
245	1	0	_aTumors of the Central Nervous System, Volume 8 _h[electronic resource] : _bAstrocytoma, Medulloblastoma, Retinoblastoma, Chordoma, Craniopharyngioma, Oligodendroglioma, and Ependymoma / _cedited by M.A. Hayat.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2012.
300			_aXXXVII, 338 p. 50 illus., 38 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aTumors of the Central Nervous System ; _v8
520			_aWith tens of thousands of new CNS tumor cases each year in the US alone, this series of publications is a valuable aid to the diagnosis and treatment of these problematic neoplasms. Now, the eighth in the set returns to the topic of brain tumors, dealing with seven distinct types: astrocytoma, medulloblastoma, retinoblastoma, chordoma, craniopharyngioma, oligodendroglioma, and ependymoma. After updating the classification of medulloblastoma the volume provides an overview of ependymoma as well as describing the delineation of prognosis based on the genetic aberrations of the latter patients. The material offers key insights into the molecular pathways involved in tumor biology, such as the role of E-cadherin gene instability, carbonic anhydrase II, urokinase plasminogen activator, and Wnt signaling in meningioma.                                                        Contributors explain the genetic and clinical features associated with recurring meningioma, including the role played by erythropoietin receptor, and examine the way in which OTX2 transcription factor functions as an oncogene in medulloblastoma. With much more besides, including discussion of the molecular mechanisms that result in resistance to chemotherapy in medulloblastoma, this volume and its companions have a positive role to play in inspiring a new generation of researchers to design new drugs that are better targeted—and thus more effective.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aNeurosciences.
650		0	_aPathology.
650		0	_aEmergency medicine.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aOncology.
650	2	4	_aPathology.
650	2	4	_aNeurosciences.
650	2	4	_aPrimary Care Medicine.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400742123
830		0	_aTumors of the Central Nervous System ; _v8
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-4213-0
912			_aZDB-2-SME
999			_c104734 _d104734