000 03270nam a22004575i 4500
001 978-94-007-4138-6
003 DE-He213
005 20140220083345.0
007 cr nn 008mamaa
008 120510s2012 ne | s |||| 0|eng d
020 _a9789400741386
_9978-94-007-4138-6
024 7 _a10.1007/978-94-007-4138-6
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aSazanov, Leonid.
_eeditor.
245 1 2 _aA Structural Perspective on Respiratory Complex I
_h[electronic resource] :
_bStructure and Function of NADH:ubiquinone oxidoreductase /
_cedited by Leonid Sazanov.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2012.
300 _aX, 286p. 46 illus., 13 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
520 _aComplex I (NADH:ubiquinone oxidoreductase) is the first and largest enzyme of the respiratory chain in mitochondria and plays a central role in cellular energy production. Complex I dysfunction has been implicated in many human neurodegenerative diseases, including Parkinson’s. Mutations in complex I subunits are among the most common human genetic disorders known. Until recently, in the absence of structural information, complex I was the least understood enzyme of the respiratory chain. The mechanism by which it couples electron transfer between NADH and quinone to the translocation of protons across the membrane was a complete enigma. Recent years have been marked by spectacular progress in the elucidation of complex I’s structure, finally allowing the interpretation of a wealth of data accumulated in about 50 years since the discovery of the enzyme. Understanding of the mechanism of this large molecular machine, involving long-range conformational changes, is beginning to emerge. This book is the first devoted entirely to complex I. It contains chapters written by leaders in the field, covering a wide range of topics from the structure of the complex, properties of its many redox centers, subunit composition, mutagenesis studies, evolution of the enzyme and on to the current understanding of the coupling mechanism and the molecular basis for human pathologies. Features: - Concise and authoritative review of current state-of-the-art in research on respiratory complex I - The first book entirely devoted to complex I, a central enzyme in bioenergetics - Recent breakthroughs in structure elucidation finally allow understanding of the mechanism - Mutations leading to common and severe human disorders are discussed.
650 0 _aMedicine.
650 0 _aBiochemistry.
650 0 _aCell membranes.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aBiochemistry, general.
650 2 4 _aProtein Structure.
650 2 4 _aMembrane Biology.
650 2 4 _aMolecular Medicine.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400741379
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-4138-6
912 _aZDB-2-SBL
999 _c104718
_d104718