000			03983nam a22004935i 4500
001			978-94-007-2863-9
003			DE-He213
005			20140220083343.0
007			cr nn 008mamaa
008			120206s2012 ne | s |||| 0|eng d
020			_a9789400728639 _9978-94-007-2863-9
024	7		_a10.1007/978-94-007-2863-9 _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aCleophas, Ton J. _eauthor.
245	1	0	_aStatistics Applied to Clinical Studies _h[electronic resource] / _cby Ton J. Cleophas, Aeilko H. Zwinderman.
250			_a5th ed. 2012.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2012.
300			_aXXXV, 743p. 186 illus. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
520			_aThanks to the omnipresent computer, current statistics can include data files of many thousands of values, and can perform any exploratory analysis in less than seconds. This development, however fascinating, generally does not lead to simple results. We should not forget that clinical studies are, mostly, for confirming prior hypotheses based on sound arguments, and the simplest tests provide the best power and are adequate for such studies. In the past few years the authors of this 5th edition, as teachers and research supervisors in academic and top-clinical facilities, have been able to closely observe the latest developments in the field of clinical data analysis, and they have been able to assess their performance. In this 5th edition the 47 chapters of the previous edition have been maintained and upgraded according to the current state of the art, and 20 novel chapters have been added after strict selection of the most valuable and promising novel methods. The novel methods are explained using practical examples and step-by-step analyses readily accessible for non-mathematicians. All of the novel chapters have been internationally published by the authors in peer-reviewed journal, including the American Journal of Therapeutics, the European Journal of Clinical Investigation, The International journal of Clinical Pharmacology and therapeutics, and other journals, and permission is granted by all of them to use this material in the current book. We should add that the authors are well-qualified in their fields of knowledge. Professor Zwinderman is president-elect of the International Society of Biostatistics, and Professor Cleophas is past-president of the American College of Angiology. From their expertise they should be able to make adequate selections of modern methods for clinical data analysis for the benefit of physicians, students, and investigators. The authors, although from a different discipline, one clinician and one statistician, have been working and publishing together for over 10 years, and their research of statistical methodology can be characterized as a continued effort to demonstrate that statistics is not mathematics but rather a discipline at the interface of biology and mathematics. They firmly believe that any reader can benefit from this clinical approach to statistical data analysis.
650		0	_aMedicine.
650		0	_aMedical laboratories.
650		0	_aInternal medicine.
650		0	_aStatistics.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aLaboratory Medicine.
650	2	4	_aStatistics, general.
650	2	4	_aStatistics for Life Sciences, Medicine, Health Sciences.
650	2	4	_aInternal Medicine.
700	1		_aZwinderman, Aeilko H. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400728622
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-2863-9
912			_aZDB-2-SBL
999			_c104592 _d104592