000			03582nam a22005535i 4500
001			978-94-007-2816-5
003			DE-He213
005			20140220083343.0
007			cr nn 008mamaa
008			111122s2012 ne | s |||| 0|eng d
020			_a9789400728165 _9978-94-007-2816-5
024	7		_a10.1007/978-94-007-2816-5 _2doi
050		4	_aQH588.S83
072		7	_aPSAK _2bicssc
072		7	_aSCI017000 _2bisacsh
072		7	_aSCI049000 _2bisacsh
082	0	4	_a571.6 _223
100	1		_aHeine, Vivi M. _eauthor.
245	1	0	_aInduced Pluripotent Stem Cells in Brain Diseases _h[electronic resource] : _bUnderstanding the Methods, Epigenetic Basis, and Applications for Regenerative Medicine. / _cby Vivi M. Heine, Stephanie Dooves, Dwayne Holmes, Judith Wagner.
264		1	_aDordrecht : _bSpringer Netherlands, _c2012.
300			_aXV, 59p. 7 illus., 6 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aSpringerBriefs in Neuroscience, _x2191-558X
505	0		_aI. Introduction.- II. Cell Reprogramming: A New Era in Regenerative Medicine -- a. Stem Cells -- b. Reprogramming Methods.- c. Measuring Pluripotency, Efficiency, and Identity -- d. Induced Pluripotent Stem Cells versus Embryonic Stem Cells -- III. Understanding Epigenetic Memory is the Key to Successful Reprogramming -- a. Pre-fertilization to Embryo -- b. Epigenetic Control in De-, Re-, and Trans-differentiation -- IV. Prospects for Cell Replacement Therapies for Brain Diseases -- a. Parkinson’s Disease -- b. Childhood Brain White Matter Disorders -- V. Conclusions.- VI. Acknowledgement -- VII. References.
520			_aThe principle goal of regenerative medicine is the restoration of damaged, dysfunctional, or missing cellular tissue, up to and including whole organs. Growing healthy replacement tissue, in vivo or in vitro, plays an important role in anticipated therapies. To generate competent replacement material, scientists confront the fundamental issues of cellular identity and plasticity. The basis of this book is formed by the theses of three talented master students: Stephanie Dooves, Dwayne Holmes and Judith Wagner. Their work discusses the recent advancements in the field of cell reprogramming. Although it is clear that we can produce pluripotent stem cells from differentiated cells, there are still a lot of unsolved issues. These issues include the efficiency and safety of reprogramming, the similarity of induced pluripotent (iPSCs) to embryonic stem cells (ESCs) and the epigenetic status of the cells. In the third chapter, the use of stem cell therapy for brain diseases will be discussed, with a focus on Parkinson’s disease (PD) and Vanishing White Matter (VWM).
650		0	_aLife sciences.
650		0	_aNeurosciences.
650		0	_aNeurology.
650		0	_aPediatrics.
650		0	_aStem cells.
650	1	4	_aLife Sciences.
650	2	4	_aStem Cells.
650	2	4	_aNeurology.
650	2	4	_aPediatrics.
650	2	4	_aNeurosciences.
700	1		_aDooves, Stephanie. _eauthor.
700	1		_aHolmes, Dwayne. _eauthor.
700	1		_aWagner, Judith. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400728158
830		0	_aSpringerBriefs in Neuroscience, _x2191-558X
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-2816-5
912			_aZDB-2-SBL
999			_c104577 _d104577