000			02942nam a22005055i 4500
001			978-94-007-2467-9
003			DE-He213
005			20140220083341.0
007			cr nn 008mamaa
008			111024s2012 ne | s |||| 0|eng d
020			_a9789400724679 _9978-94-007-2467-9
024	7		_a10.1007/978-94-007-2467-9 _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aTakayama, Yoshiharu. _eauthor.
245	1	0	_aLactoferrin and its Role in Wound Healing _h[electronic resource] / _cby Yoshiharu Takayama.
264		1	_aDordrecht : _bSpringer Netherlands, _c2012.
300			_aXII, 108 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
520			_a“Lactoferrin and its Role in Wound Healing” summarizes the recent advances of molecular mechanisms of wound healing. It is a complex physiological process that requires the regulation of different types of cells such as immune cells, keratinocytes, fibroblasts, and endothelial cells. Lactoferrin was first identified as an iron-binding glycoprotein abundantly found in milk. It has been considered to play important roles in host defense, since lactoferrin shows broad spectrum of anti-bacterial and anti-viral activities, arising from its iron-chelating property. Furthermore, lactoferrin can regulate the function of innate and adaptive immune cells and exhibits immuno-modulating properties. These activities of lactoferrin implicate that potential use of lactoferrin as a wound healing agent. In addition, this book shows that lactoferrin is a potent regulator of dermal fibroblasts and epidermal keratinocytes, and promotes skin or corneal epithelial wound healing by increasing their proliferation, migration or deposition of extracellular matrix (ECM) components such as collagen and hyaluronan. This book provides the scientific background on use of lactoferrin as a wound healing agent. Indeed, lactoferrin exerts its biological effects by binding to specific lactoferrin receptors on target cells. This book also covers the in-depth information on roles of lactoferrin as a signaling molecule.
650		0	_aMedicine.
650		0	_aHuman physiology.
650		0	_aBiochemistry.
650		0	_aCell receptors.
650		0	_aCytology.
650		0	_aCell membranes.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aHuman Physiology.
650	2	4	_aCell Biology.
650	2	4	_aProtein Science.
650	2	4	_aReceptors.
650	2	4	_aMembrane Biology.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400724662
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-2467-9
912			_aZDB-2-SBL
999			_c104487 _d104487