000 03933nam a22004935i 4500
001 978-94-007-1226-3
003 DE-He213
005 20140220083338.0
007 cr nn 008mamaa
008 120705s2012 ne | s |||| 0|eng d
020 _a9789400712263
_9978-94-007-1226-3
024 7 _a10.1007/978-94-007-1226-3
_2doi
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aPHVD
_2bicssc
072 7 _aSCI009000
_2bisacsh
082 0 4 _a571.4
_223
100 1 _aSpoto, Giuseppe.
_eeditor.
245 1 0 _aDetection of Non-Amplified Genomic DNA
_h[electronic resource] /
_cedited by Giuseppe Spoto, Roberto Corradini.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2012.
300 _aXIV, 315 p. 90 illus., 68 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSoft and Biological Matter,
_x2213-1736
505 0 _aPreface -- List of contributors -- Part I DNA analysis: current issues -- 1 Genetic analyses in health laboratories: current status and expectations -- 2 DNA analyses in food safety and quality: current status and expectations -- Part II Advanced materials for ultrasensitive analysis -- 3 Engineered nanostructures for ultrasensitive DNA detection -- 4 Advanced molecular probes for sequence-specific DNA recognition -- 5 Charged conjugated polymers -- 6 Optical detection of non-amplified genomic DNA -- 7 Electrochemical detection of DNA using nanomaterials-based sensors -- 8 Piezoelectric sensing for sensitive detection of DNA -- 9 Surface plasmon resonance-based methods -- 10 Parallel optical and electrochemical DNA detection -- 11 Recent advances in DNA sequencing technologies -- Subject Index.
520 _aThis book offers a state-of-the-art overview on non amplified DNA detection methods and provides chemists, biochemists, biotechnologists and material scientists with an introduction to these methods. In fact all these fields have dedicated resources to the problem of nucleic acid detection, each contributing with their own specific methods and concepts. This book will explain the basic principles of the different non amplified DNA detection methods available, highlighting their respective advantages and limitations. The importance of non-amplified DNA sequencing technologies will be also discussed. Non-amplified DNA detection can be achieved by adopting different techniques. Such techniques have allowed the commercialization of innovative platforms for DNA detection that are expected to break into the DNA diagnostics market. The enhanced sensitivity required for the detection of non amplified genomic DNA has prompted new strategies that can achieve ultrasensitivity by combining specific materials with specific detection tools. Advanced materials play multiple roles in ultrasensitive detection. Optical and electrochemical detection tools are among the most widely investigated to analyze non amplified nucleic acids. Biosensors based on piezoelectric crystal have been also used to detect unamplified genomic DNA. The main scientific topics related to DNA diagnostics are discussed by an outstanding set of authors with proven experience in the field.
650 0 _aPhysics.
650 0 _aAnalytical biochemistry.
650 0 _aBiomedical engineering.
650 1 4 _aPhysics.
650 2 4 _aBiophysics and Biological Physics.
650 2 4 _aAnalytical Chemistry.
650 2 4 _aBiomedical Engineering.
700 1 _aCorradini, Roberto.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400712256
830 0 _aSoft and Biological Matter,
_x2213-1736
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-1226-3
912 _aZDB-2-PHA
999 _c104289
_d104289