000			05188nam a22005415i 4500
001			978-88-470-2571-4
003			DE-He213
005			20140220083336.0
007			cr nn 008mamaa
008			130125s2012 it | s |||| 0|eng d
020			_a9788847025714 _9978-88-470-2571-4
024	7		_a10.1007/978-88-470-2571-4 _2doi
050		4	_aQH323.5
072		7	_aPBW _2bicssc
072		7	_aMAT003000 _2bisacsh
082	0	4	_a570.285 _223
100	1		_ad’Onofrio, Alberto. _eeditor.
245	1	0	_aNew Challenges for Cancer Systems Biomedicine _h[electronic resource] / _cedited by Alberto d’Onofrio, Paola Cerrai, Alberto Gandolfi.
264		1	_aMilano : _bSpringer Milan : _bImprint: Springer, _c2012.
300			_aXI, 398 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aSIMAI Springer Series, _x2280-840X
505	0		_aPart I Towards a Comprehensive Theory of Cancer Growth -- Combining Game Theory and Graph Theory to Model Interactions between Cells in the Tumor Microenvironment -- Growth as the Root of all Evil in Carcinomas: Synergy between pH Buffering and Anti-Angiogenesis prevents Emergence of Hallmarks of Cancer -- Phase Transitions in Cancer -- Part II Cancer Related Signalling Pathways -- Spatio-Temporal Modelling of Intracellular Signalling Pathways: Transcription Factors, Negative Feedback Systems and Oscillations -- Understanding Cell Fate Decisions by Identifying Crucial System Dynamics -- Modelling Biochemical Pathways with the Calculus of Looping Sequences -- Dynamic Simulations of Pathways Downstream of TGFβ, Wnt and EGF-Family Growth Factors, in Colorectal Cancer, including Mutations and Treatments with Onco-Protein Inhibitors -- Part III Basic Mechanisms of Tumor Progression -- Some Results on the Population Behavior of Cancer Stem Cells -- Glucose Metabolism in Multicellular Spheroids, ATP Production and Effects of Acidity -- Cell-Cell Interactions in Solid Tumors - the Role of Cancer Stem Cells -- Hybrid Cellular Potts Model for Solid Tumor Growth -- Part IV Tumor-Immune System Interplay and Immunotherapy -- Computational Models as Novel Tools for Cancer Vaccines -- On the Dynamics of Tumor-Immune System Interactions and Combined Chemo- and Immunotherapy -- Modeling the Kinetics of the Immune Response -- Part V Computational Method for Improving Chemotherapy.- Optimizing Cancer Chemotherapy: from Mathematical Theories to Clinical Treatment -- A Systems Biomedicine Approach for Chronotherapeutics Optimization: Focus on the Anticancer Drug Irinotecan -- Modeling the Dynamics of HCV Infected Cells to Tailor Antiviral Therapy in Clinical Practice: Can This Approach Fit for Neoplastic Cells? -- Introducing Drug Transport Early in the Design of Hypoxia Selective Anticancer Agents Using a Mathematical Modelling Approach -- Top-Down Multiscale Simulation of Tumor Response to Treatment in the Context of In Silico Oncology. The Notion of Oncosimulator -- Challenges in the Integration of Flow Cytometry and Time-Lapse Live Cell Imaging Data Using a Cell Proliferation Model.
520			_aThe aim of this book is not only to illustrate the state of the art of tumor systems biomedicine, but also and mainly to explicitly capture the fact that a increasing number of biomedical scientists is now directly working on mathematical modeling, and a larger number are collaborating with bio-mathematical scientists. Moreover, a number of biomathematicians started working in biomedical institutions. The book is characterized by a coherent view of tumor modeling, based on the concept that mathematical modeling is (with medicine and molecular biology) one of the three pillars of molecular medicine. Indeed this volume is characterized by a well-structured presence of a large number of biomedical scientists directly working in Mathematical or Systems Biomedicine, and of a number biomathematicians working in hospitals. This give to this book an unprecedented tone, providing an original interdisciplinary insight into the biomedical applications. Finally, all biomedical contributors were asked to briefly summarize in one section of their contributes their point of view on her/his own interactions with quantitative scientists working in Systems Biomedicine.
650		0	_aMathematics.
650		0	_aOncology.
650		0	_aImmunology.
650		0	_aDifferential equations, partial.
650		0	_aPhysiology _xMathematics.
650	1	4	_aMathematics.
650	2	4	_aPhysiological, Cellular and Medical Topics.
650	2	4	_aCancer Research.
650	2	4	_aBiophysics and Biological Physics.
650	2	4	_aPartial Differential Equations.
650	2	4	_aImmunology.
700	1		_aCerrai, Paola. _eeditor.
700	1		_aGandolfi, Alberto. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9788847025707
830		0	_aSIMAI Springer Series, _x2280-840X
856	4	0	_uhttp://dx.doi.org/10.1007/978-88-470-2571-4
912			_aZDB-2-SMA
999			_c104169 _d104169