000 03511nam a22004815i 4500
001 978-3-7091-1206-9
003 DE-He213
005 20140220083332.0
007 cr nn 008mamaa
008 121213s2012 au | s |||| 0|eng d
020 _a9783709112069
_9978-3-7091-1206-9
024 7 _a10.1007/978-3-7091-1206-9
_2doi
050 4 _aQH506
072 7 _aMBGR
_2bicssc
072 7 _aPSD
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aMED067000
_2bisacsh
082 0 4 _a611.01816
_223
100 1 _aSebestik, Jaroslav.
_eauthor.
245 1 0 _aBiomedical Applications of Peptide-, Glyco- and Glycopeptide Dendrimers, and Analogous Dendrimeric Structures
_h[electronic resource] /
_cby Jaroslav Sebestik, Milan Reinis, Jan Jezek.
264 1 _aVienna :
_bSpringer Vienna :
_bImprint: Springer,
_c2012.
300 _aXVII, 238 p. 29 illus., 19 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aIntroduction -- Chemistry and struture to dendrimers: Definition of terms and nomenclature -- Sugar code (glyco code) -- Classes of peptide-, glyco, and glycopeptide dendrimers -- The dendritic state and dendritic effects -- Synthesis of dendrimers: convergent and divergent approaches -- Purification and characterization of dendrimers -- Dendrimeric libraries -- Dendrimers in catalysis.-Dendrimers and their biological and therapeutic applications: Dendrimers and solubility -- Biocompability and toxicity of dendrimers -- Dendrimers in nanoscience and nanotechnology -- Dendrimers in drug delivery -- Dendrimers in gene delivery.-Dendrimers and bacteria -- Dendrimers and viruses -- Dendrimers and parasites -- Cancer -- Diagnostics, lectin detection and cell-cell interactions -- Dendrimers as biosensors and imaging tools -- Dendrimers regulating in intracellular signaling pathways -- Vaccines and immunomodulation -- Dendrimers in neurodegenerative diseases -- Conclusions and persperctives. .
520 _aDendrimers are repeatedly branched and roughly spherical large molecules. They can be used in various medical applications, such as anticancer polymeric nanomedicines and nanocarriers, gene carriers and vectors in gene delivery, contrast agents for molecular imaging and vaccines against infectious diseases and cancer. The highly branched, multivalent nature and molecular architecture of dendrimers make them ideal tools for a variety of tissue engineering applications. This book describes different categories of dendrimers, their biomedical and physico-chemical applications as well as convergent and divergent syntheses, click chemistry and ligation strategies. It is a rich source of information for researchers in biochemistry and pharmacology working on drug development as well as for organic chemists who are engaged in synthesis of dendrimers.
650 0 _aMedicine.
650 0 _aPharmaceutical technology.
650 1 4 _aBiomedicine.
650 2 4 _aMolecular Medicine.
650 2 4 _aBiomedicine general.
650 2 4 _aPharmaceutical Sciences/Technology.
700 1 _aReinis, Milan.
_eauthor.
700 1 _aJezek, Jan.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783709112052
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-7091-1206-9
912 _aZDB-2-SBL
999 _c103934
_d103934