000 04517nam a22004695i 4500
001 978-3-7091-0947-2
003 DE-He213
005 20140220083332.0
007 cr nn 008mamaa
008 120918s2012 au | s |||| 0|eng d
020 _a9783709109472
_9978-3-7091-0947-2
024 7 _a10.1007/978-3-7091-0947-2
_2doi
050 4 _aQH506
072 7 _aMBGR
_2bicssc
072 7 _aPSD
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aMED067000
_2bisacsh
082 0 4 _a611.01816
_223
100 1 _aTrajanoski, Zlatko.
_eeditor.
245 1 0 _aComputational Medicine
_h[electronic resource] :
_bTools and Challenges /
_cedited by Zlatko Trajanoski.
264 1 _aVienna :
_bSpringer Vienna :
_bImprint: Springer,
_c2012.
300 _aIX, 203 p. 25 illus., 19 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _a1. Bioinformatics tools for the search of disease-associated variations. Stefan Coassin, Anita Kloss-Brandstätter, Florian Kronenberg -- 2. Cloud computing: bringing computational power to medical genetics. Lukas Forer, Sebastian Schönherr, Hansi Weißensteiner, Günther Specht, Florian Kronenberg, Anita Kloss-Brandstätter -- 3. High-throughput characterization and comparison of microbial communities. Bettina Halwachs, Gregor Gorkiewicz, Gerhard G. Thallinger -- 4. Microarray Meta-Analysis: From Data to Expression to Biological Relationships. Julia Feichtinger, Gerhard G. Thallinger, Ramsay J. McFarlane, Lee Larcombe -- 5. Analysis of labeled quantitative mass spectrometry proteomics data. Florian Breitwieser, Jacques Colinge -- 6. Lipidomics, Mass Spectrometry and Bioinformatics. Jürgen Hartler, Harald C. Köfeler, Christopher J.O. Baker, Ravi Tharakan, Gerhard G. Thallinger -- 7. Protein sequence-structure-function-network links discoveries with the ANNOTATOR software suite: Application to ELYS/Mel-28analysis. Georg Schneider, Westley Sherman, Durga Kuchibhatla, Ooi Hong Sain, Fernanda L. Sirota, Sebastian Maurer-Stroh, Birgit Eisenhaber, Frank Eisenhaber -- 8. 3D structure and drug design. Kristina Djinovic-Carugo, Oliviero Carugo -- 9. Integrating biomolecular and clinical data for cancer research: concepts and challenges. Pornpimol Charoentong, Hubert Hackl, Bernhard Mlecnik, Gabriela Bindea, Jerome Galon, Zlatko Trajanoski -- 10. Applied data mining: from biomarker discovery to decision support systems. Melanie Osl, Michael Netzer, S. Dreiseitl, Christian Baumgartner -- 11. Network-based methods for computational diagnostics by means of R. Laurin A.J. Müller, Mathias Dehmer, Frank Emmert-Streib.
520 _aComputational methodologies and modeling play a growing role for investigating mechanisms, and for the diagnosis and therapy of human diseases. This progress gave rise to computational medicine, an interdisciplinary field at the interface of computer science and medicine. The main focus of computational medicine lies in the development of data analysis methods and mathematical modeling as well as computational simulation techniques specifically addressing medical problems. In this book, we present a number of computational medicine topics at several scales: from molecules to cells, organs, and organisms. At the molecular level, tools for the analysis of genome variations as well as cloud computing resources for medical genetics are reviewed. Then, an analysis of gene expression data and the application to the characterization of microbial communities are highlighted. At the protein level, two types of analyses for mass spectrometry data are reviewed: labeled quantitative proteomics and lipidomics, followed by protein sequence analysis and a 3D structure and drug design chapter. Finally, three chapters on clinical applications focus on the integration of biomolecular and clinical data for cancer research, biomarker discovery, and network-based methods for computational diagnostics.
650 0 _aMedicine.
650 0 _aBioinformatics.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aMolecular Medicine.
650 2 4 _aBioinformatics.
650 2 4 _aCell Biology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783709109465
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-7091-0947-2
912 _aZDB-2-SBL
999 _c103922
_d103922