000 05256nam a22005535i 4500
001 978-3-7091-0891-8
003 DE-He213
005 20140220083332.0
007 cr nn 008mamaa
008 120605s2012 au | s |||| 0|eng d
020 _a9783709108918
_9978-3-7091-0891-8
024 7 _a10.1007/978-3-7091-0891-8
_2doi
050 4 _aQH588.S83
072 7 _aPSAK
_2bicssc
072 7 _aSCI017000
_2bisacsh
072 7 _aSCI049000
_2bisacsh
082 0 4 _a571.6
_223
100 1 _aDecker, Thomas.
_eeditor.
245 1 0 _aJak-Stat Signaling : From Basics to Disease
_h[electronic resource] /
_cedited by Thomas Decker, Mathias Müller.
264 1 _aVienna :
_bSpringer Vienna :
_bImprint: Springer,
_c2012.
300 _aXIII, 448 p. 45 illus., 34 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aThe continuing fascination with Jaks and Stats: An introduction -- Regulation of JAKs: Insights gleaned from the functional protein domains -- Nuclear functions of the Janus Kinases -- Self-association of STAT proteins from monomers to paracrystals -- How Stats interact with the molecular machinery of transcriptional activation -- Nongenomic Functions of STAT3 .-Evolution of Jak and Stat proteins -- JAK/STAT and chromatin regulation in Drosophila . JAK/STAT signaling and invertebrate immune responses -- Stat5 as a hematopoietic master regulator for differentiation and neoplasia development -- Regulation of dendritic cell development by STATs -- STAT transcription factors – Controlling all aspects of NK cell biology -- Function of JAKs and STATs in lymphocytes: Bench to bedside -- The role of Janus kinases in hematopoietic malignancies -- Activation of Janus kinases during tumorigenesis . STAT1 and STAT3 transcription factors in inflammation-associated colon cancer -- Universal and specific functions of STAT3 in solid tumours -- Impact of STAT5 on normal tissue development and cancer -- Crosstalk with the Jak-STAT pathway in inflammation -- Activation and inhibition of JAK-STAT signal transduction by RNA viruses -- Multifaceted antiviral actions of interferon-stimulated gene products -- Interferon regulation of the innate response to bacteriaEvolution of Jak and Stat proteins -- JAK/STAT and chromatin regulation in Drosophila . JAK/STAT signaling and invertebrate immune responses -- Stat5 as a hematopoietic master regulator for differentiation and neoplasia development -- Regulation of dendritic cell development by STATs -- STAT transcription factors – Controlling all aspects of NK cell biology -- Function of JAKs and STATs in lymphocytes: Bench to bedside -- The role of Janus kinases in hematopoietic malignancies -- Activation of Janus kinases during tumorigenesis . STAT1 and STAT3 transcription factors in inflammation-associated colon cancer -- Universal and specific functions of STAT3 in solid tumours -- Impact of STAT5 on normal tissue development and cancer -- Crosstalk with the Jak-STAT pathway in inflammation -- Activation and inhibition of JAK-STAT signal transduction by RNA viruses -- Multifaceted antiviral actions of interferon-stimulated gene products -- Interferon regulation of the innate response to bacteria.
520 _aJAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.
650 0 _aLife sciences.
650 0 _aOncology.
650 0 _aMedical genetics.
650 0 _aImmunology.
650 0 _aHematology.
650 0 _aCytology.
650 0 _aStem cells.
650 1 4 _aLife Sciences.
650 2 4 _aStem Cells.
650 2 4 _aCell Biology.
650 2 4 _aCancer Research.
650 2 4 _aImmunology.
650 2 4 _aHematology.
650 2 4 _aGene Function.
700 1 _aMüller, Mathias.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783709108901
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-7091-0891-8
912 _aZDB-2-SBL
999 _c103918
_d103918