000 03633nam a22004935i 4500
001 978-3-7091-0439-2
003 DE-He213
005 20140220083332.0
007 cr nn 008mamaa
008 110830s2012 au | s |||| 0|eng d
020 _a9783709104392
_9978-3-7091-0439-2
024 7 _a10.1007/978-3-7091-0439-2
_2doi
050 4 _aRM281
050 4 _aQR189-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a615.372
_223
100 1 _aThalhamer, Josef.
_eeditor.
245 1 0 _aGene Vaccines
_h[electronic resource] /
_cedited by Josef Thalhamer, Richard Weiss, Sandra Scheiblhofer.
264 1 _aVienna :
_bSpringer Vienna :
_bImprint: Springer,
_c2012.
300 _aXI, 330 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- 1 General mechanisms of gene vaccines -- 2 Strategies to Improve DNA Vaccine Potency: HPV-associated Cervical Cancer as a Model System -- 3 Immune-activating mechanisms of replicase-based DNA and RNA vaccines and their role in immune-apoptosis -- 4 Cytokine genes as molecular adjuvants for DNA vaccines -- 5 Pharmaceutical non-viral formulations for gene vaccines -- 6 Rational design of formulated DNA vaccines: the DermaVir approach -- 7 In vivo electroporation -- 8 Electroporation-based Trigrid™ delivery system (TDS) for DNA vaccine administration -- 9 Prime Boost Regimens for Enhancing Immunity: Magnitude, Quality of Mucosal and Systemic Gene Vaccines -- 10 Intranodal genetic immunization -- 11 Immunotherapy of cancer with RNA vaccines -- 12 DNA and RNA vaccines for prophylactic and therapeutic treatment of type I allergy -- 13 Approved veterinary vaccines – paving the way to products for human use -- 14 Current status of regulations for DNA vaccines -- 15 State of the art production of antibiotic resistance-free plasmid DNA -- 16 Industrial Manufacturing of Plasmid-DNA Products for Gene Vaccination and Therapy.  .
520 _aThe induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aVaccines.
650 0 _aBiochemistry.
650 1 4 _aBiomedicine.
650 2 4 _aVaccine.
650 2 4 _aImmunology.
650 2 4 _aMedical Biochemistry.
700 1 _aWeiss, Richard.
_eeditor.
700 1 _aScheiblhofer, Sandra.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783709104385
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-7091-0439-2
912 _aZDB-2-SBL
999 _c103906
_d103906