000			02812nam a22005295i 4500
001			978-3-7091-0418-7
003			DE-He213
005			20140220083332.0
007			cr nn 008mamaa
008			111031s2012 au | s |||| 0|eng d
020			_a9783709104187 _9978-3-7091-0418-7
024	7		_a10.1007/978-3-7091-0418-7 _2doi
050		4	_aRS380
050		4	_aRS190-210
072		7	_aTDCW _2bicssc
072		7	_aMED072000 _2bisacsh
082	0	4	_a615.19 _223
100	1		_aMosekilde, Erik. _eeditor.
245	1	0	_aBiosimulation in Biomedical Research, Health Care and Drug Development _h[electronic resource] / _cedited by Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan.
264		1	_aVienna : _bSpringer Vienna : _bImprint: Springer, _c2012.
300			_aXVI, 396 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
520			_aBiosimulation is an approach to biomedical research and the treatment of patients in which computer modeling goes hand in hand with experimental and clinical work. Constructed models are used to interpret experimental results and to accumulate information from experiment to experiment. The book explains the concepts used in the modeling of biological phenomena and goes on to present a series of well-documented models of the regulation of various cellular and physiological processes, emphasizing particularly the role of self-sustained biological activity. The way how the use of computer models allows optimization of the treatment of various diseases for individual patients is discussed and models of interacting nerve cells that can be used to design new treatments for patients with Parkinson's disease are explained. Furthermore this volume provides a discussion of the use of models in the pharmaceutical industry, and presents the view of the regulatory agencies on the topic.
650		0	_aMedicine.
650		0	_aPharmaceutical technology.
650		0	_aPharmacy.
650		0	_aBioinformatics.
650		0	_aStatistics.
650	1	4	_aBiomedicine.
650	2	4	_aPharmaceutical Sciences/Technology.
650	2	4	_aPharmacy.
650	2	4	_aMedicine/Public Health, general.
650	2	4	_aBiophysics and Biological Physics.
650	2	4	_aComputational Biology/Bioinformatics.
650	2	4	_aStatistics for Life Sciences, Medicine, Health Sciences.
700	1		_aSosnovtseva, Olga. _eeditor.
700	1		_aRostami-Hodjegan, Amin. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783709104170
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-7091-0418-7
912			_aZDB-2-SBL
999			_c103904 _d103904