000 02814nam a22004695i 4500
001 978-3-642-30726-3
003 DE-He213
005 20140220083319.0
007 cr nn 008mamaa
008 121009s2012 gw | s |||| 0|eng d
020 _a9783642307263
_9978-3-642-30726-3
024 7 _a10.1007/978-3-642-30726-3
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aRegitz-Zagrosek, Vera.
_eeditor.
245 1 0 _aSex and Gender Differences in Pharmacology
_h[electronic resource] /
_cedited by Vera Regitz-Zagrosek.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2012.
300 _aIX, 600 p. 37 illus., 22 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aHandbook of Experimental Pharmacology,
_x0171-2004 ;
_v214
505 0 _aFrom the contents -- Preface -- Part 1: Sex differences in mechanisms of disease -- Part 2: Sex differences in pharmaco­kinetics, in drug development and use -- Part 3: Sex differences in different therapeutic areas.
520 _aThis is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.
650 0 _aMedicine.
650 0 _aToxicology.
650 0 _aPharmaceutical technology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aMolecular Medicine.
650 2 4 _aPharmaceutical Sciences/Technology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642307256
830 0 _aHandbook of Experimental Pharmacology,
_x0171-2004 ;
_v214
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-30726-3
912 _aZDB-2-SBL
999 _c103233
_d103233