000			03530nam a22004215i 4500
001			978-3-642-28863-0
003			DE-He213
005			20140220083314.0
007			cr nn 008mamaa
008			120604s2012 gw | s |||| 0|eng d
020			_a9783642288630 _9978-3-642-28863-0
024	7		_a10.1007/978-3-642-28863-0 _2doi
050		4	_aQP34-38
072		7	_aMFG _2bicssc
072		7	_aMED075000 _2bisacsh
082	0	4	_a612 _223
100	1		_aBurnstock, Geoffrey. _eauthor.
245	1	0	_aPurinergic Signalling and the Nervous System _h[electronic resource] / _cby Geoffrey Burnstock, Alexei Verkhratsky.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2012.
300			_aXVIII, 715 p. 135 illus., 46 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aIntroduction -- Early history of purinergic signaling -- Purinergic cotransmission -- Mechanisms of ATP release and inactivation -- Receptors for purines and pyrimidines -- Evolution of purinergic signaling -- Peripheral nervous system -- Purinergic signalling in the central nervous system -- Sensory Nerves -- Special senses -- Ontogeny of purinergic neurotransmission.
520			_aIn the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents. In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.
650		0	_aMedicine.
650		0	_aHuman physiology.
650	1	4	_aBiomedicine.
650	2	4	_aHuman Physiology.
700	1		_aVerkhratsky, Alexei. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642288623
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-28863-0
912			_aZDB-2-SBL
999			_c102906 _d102906