000 03358nam a22005055i 4500
001 978-3-642-28687-2
003 DE-He213
005 20140220083313.0
007 cr nn 008mamaa
008 120611s2012 gw | s |||| 0|eng d
020 _a9783642286872
_9978-3-642-28687-2
024 7 _a10.1007/978-3-642-28687-2
_2doi
050 4 _aQD433-436
072 7 _aPSB
_2bicssc
072 7 _aSCI007000
_2bisacsh
082 0 4 _a572.84
_223
100 1 _aBindereif, Albrecht.
_eeditor.
245 1 0 _aRNA Metabolism in Trypanosomes
_h[electronic resource] /
_cedited by Albrecht Bindereif.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2012.
300 _aVI, 271 p. 27 illus., 22 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aNucleic Acids and Molecular Biology,
_x0933-1891 ;
_v28
505 0 _aRNA Polymerases and Transcription Factors of Trypanosomes -- SL RNA biogenesis in kinetoplastids: a long and winding road -- Pre-mRNA splicing in Trypanosoma brucei: factors, mechanisms, and regulation -- mRNA turnover in trypanosomes -- tRNA biogenesis and processing -- rRNA biogenesis in trypanosomes -- RNA Editing in African Trypanosomes – a User’s Guide -- The RNA Interference Pathway in Trypanosoma brucei -- Translation in trypanosomatids -- Mitochondrial translation in trypanosomatids -- RNA-Seq analysis of the transcriptome of Trypanosoma brucei.
520 _aTrypanosomes are unicellular protozoa of ancient evolutionary origin that are responsible for several tropical diseases, such as African sleeping sickness. Over the last few decades, research in trypanosome biology has revealed many unique and fascinating features, many of which have helped to establish new paradigms in other biological systems. This applies in particular to studies in gene expression and regulation, which benefit enormously from the trypanosome genome projects and from the new genome-wide approaches recently introduced in trypanosome research. This volume covers the most important aspects of biosynthesis, processing, and functions of RNA in trypanosomes, ranging from transcription to RNA editing, mRNA splicing/translation/turnover, processing of transfer and ribosomal RNA, RNA interference, and current transcriptome-wide analyses. Recent progress in RNA-focused research in trypanosomatids promises to yield novel insights into trypanosome-specific features, as well as to reveal in the process new potential therapeutic strategies for combating these parasitic diseases.
650 0 _aLife sciences.
650 0 _aGene expression.
650 0 _aMedical parasitology.
650 0 _aNucleic acids.
650 0 _aMicrobiology.
650 1 4 _aLife Sciences.
650 2 4 _aNucleic Acid Chemistry.
650 2 4 _aEukaryotic Microbiology.
650 2 4 _aParasitology.
650 2 4 _aGene Expression.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642286865
830 0 _aNucleic Acids and Molecular Biology,
_x0933-1891 ;
_v28
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-28687-2
912 _aZDB-2-SBL
999 _c102866
_d102866