000			03037nam a22004335i 4500
001			978-3-642-28397-0
003			DE-He213
005			20140220083312.0
007			cr nn 008mamaa
008			121026s2012 gw | s |||| 0|eng d
020			_a9783642283970 _9978-3-642-28397-0
024	7		_a10.1007/978-3-642-28397-0 _2doi
050		4	_aRL1-803
072		7	_aMJK _2bicssc
072		7	_aMED017000 _2bisacsh
082	0	4	_a616.5 _223
100	1		_aMarghoob, Ashfaq A. _eeditor.
245	1	0	_aNevogenesis _h[electronic resource] : _bMechanisms and Clinical Implications of Nevus Development / _cedited by Ashfaq A. Marghoob.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2012.
300			_aVIII, 160 p. 60 illus., 59 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aNevogenesis: Changing Theories -- Classifying Melanocytic Nevi -- Evolution of Nevi -- The Dual Pathway of Nevogenesis -- Confocal Microscopy: Improving Our Understanding of Nevogenesis -- Nevi In Children And Adults: Dermoscopic Patterns And The Development of New Nevi -- Etiology of Congenital Melanocytic Nevi And Related Conditions -- Molecular Nevogenesis -- Nevogenesis: A Benign Metastatic Process? -- Nevus Senescence -- Gene-Environment Interactions In Nevogenesis -- Malignant Transformation of Melanocytic Nevi -- Disappearance of Melanocytic Nevi.
520			_aPaul Gerson Unna’s “Abtropfung” theory that nevi develop through migration of nevus cells from the epidermis to the dermis prevailed for almost a century until the “Hochsteigerung” theory postulated the reverse pattern of migration based on newly acquired observations from histopathology and studies of embryogenesis. Most recently, however, new insights gained from epidemiology, cross-sectional and longitudinal studies of nevi, dermoscopy and confocal microscopy, and cellular and molecular studies have brought into question both of the aforementioned theories. This book provides a comprehensive guide to current knowledge about nevogenesis by presenting these latest advances and in addition discusses issues yet to be resolved. It will assist practicing physicians in effectively managing patients with a variety of nevi and will also be of great value to researchers in the field. Importantly, since nevi are associated with an increased risk of melanoma, understanding nevogenesis may help to unravel some of the mysteries of melanomagenesis.
650		0	_aMedicine.
650		0	_aDermatology.
650		0	_aOncology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aDermatology.
650	2	4	_aOncology.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642283963
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-28397-0
912			_aZDB-2-SME
999			_c102800 _d102800