000 03189nam a22004455i 4500
001 978-3-642-28203-4
003 DE-He213
005 20140220083311.0
007 cr nn 008mamaa
008 120419s2012 gw | s |||| 0|eng d
020 _a9783642282034
_9978-3-642-28203-4
024 7 _a10.1007/978-3-642-28203-4
_2doi
050 4 _aR857.B5
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
072 7 _aSCI029000
_2bisacsh
082 0 4 _a612.01575
_223
100 1 _aJordan, Bertrand.
_eeditor.
245 1 0 _aMicroarrays in Diagnostics and Biomarker Development
_h[electronic resource] :
_bCurrent and Future Applications /
_cedited by Bertrand Jordan.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2012.
300 _aVIII, 240p. 47 illus., 21 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aThe microarray paradigm and its various implementations -- DNA arrays in many guises -- Expression profiling for diagnostics -- Genotype characterisation for diagnostics -- Array-CGH and SNP-arrays, the new karyotype -- Protein Microarrays and Their Potential Clinical Applications in the Era of Personalized Medicin -- Peptide arrays -- Slow Off-rate Modified Aptamer (SOMAmer) Arrays for Biomarker Discovery and Diagnostic Applications -- Tissue microarrays for translational research -- Recent and future developments of microarrays:  miniaturization and lab-on-chip approaches -- Analysis of array data and clinical validation of array-based assays -- Challenges in the Commercialization of Array-Based Tests -- Genes, micorarrays and patents.
520 _aMicroarray technology has made strong progress over the past decade, and there have also been significant changes in application areas, from nucleic acids to proteomics and from research to clinical applications. This book provides a comprehensive overview of microarrays in diagnostics and biomarker development, covering DNA, peptide, protein and tissue arrays. The focus is on entities that are in actual clinical use, or quite close, and on recent developments, such as peptide and aptamer arrays. A further topic is the miniaturisation towards “nanoarrays”, which is expected to have great potential in clinical applications. Relevant issues of bioinformatics and statistical analysis of array data are discussed in detail, as well as the barriers to the commercialisation of array-based tests and the vexing IP issues involved. Thus, the book should be very useful tor active array users as well as to newcomers seeking to make the best choice between different technologies.
650 0 _aMedicine.
650 0 _aDNA microarrays.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aMicroarrays.
650 2 4 _aCell Biology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642282027
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-28203-4
912 _aZDB-2-SBL
999 _c102752
_d102752