000 03794nam a22004335i 4500
001 978-3-642-27470-1
003 DE-He213
005 20140220083308.0
007 cr nn 008mamaa
008 120210s2012 gw | s |||| 0|eng d
020 _a9783642274701
_9978-3-642-27470-1
024 7 _a10.1007/978-3-642-27470-1
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aMantis, Nicholas.
_eeditor.
245 1 0 _aRicin and Shiga Toxins
_h[electronic resource] :
_bPathogenesis, Immunity, Vaccines and Therapeutics /
_cedited by Nicholas Mantis.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2012.
300 _aXI, 276p. 30 illus., 22 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v357
505 0 _aPreface -- Interaction of ricin and Stx with ribosomes and the sarcin-ricin loop -- How ricin and Stx enter and intoxicate mammalian cells -- Cellular stress response to Stx-ricin -- Ricin and Stx-Inflammation -- Pathogenesis of shiga-toxin producing E.coli -- Ricin and Stx-Interactions with the epithelium and intestinal mucosa -- Stx Pathogenesis-Kidney complications and renal failure -- Toxin-induced Apoptosis -- Small Molecule Inhibitors of Ricin and STX -- Antibody-mediated immunity to ricin -- Stx-animal models and immunotherapies -- Ricin- animal models and immunotherapies -- Ricin Vaccine Development -- Subject Index.
520 _aThe intent of this volume of Current Topics in Microbiology and Immunology was to bring together a collection of in-depth and cutting edge reviews that highlight our current understanding of the biology of ricin and Shiga toxin (Stx), with the long term goal of advancing the development of countermeasures against these toxic agents.  In May of 2011, Western Europe experienced a severe outbreak of Stx-producing E. coli (STEC) that culminated in more than 3200 cases and 39 deaths.  While Stx is not the only virulence factor associated with STEC, it is certainly the primary determinant associated with the onset of hemolytic uremic syndrome (HUS).  At the present time, there are no clinically approved measures to neutralize Stx in individuals suffering from STEC infection.  Nor are there any preventatives or therapeutics for ricin toxin.  Although incidents of ricin exposure are largely unheard of, federal agencies and public health officials consider it a significant threat.  It is well documented that domestic and international terrorist groups have stockpiled, and in some cases weaponized ricin with the intent of releasing it into the public sphere and causing panic, illness and/or death on a local, regional, or possibly national scale. As the title of this volume indicates, the chapters, written by leading experts in the field, are organized so as to cover all aspects of ricin and Stx, including pathogenesis, immunity, vaccines and therapeutics. This outstanding collection of reviews will serve as an important and readily accessible resource for the research community in the coming years.   
650 0 _aMedicine.
650 0 _aToxicology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642274695
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v357
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-27470-1
912 _aZDB-2-SBL
999 _c102597
_d102597