| 000 | 02637nam a22004815i 4500 | ||
|---|---|---|---|
| 001 | 978-3-642-27195-3 | ||
| 003 | DE-He213 | ||
| 005 | 20140220083307.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 120114s2012 gw | s |||| 0|eng d | ||
| 020 |
_a9783642271953 _9978-3-642-27195-3 |
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| 024 | 7 |
_a10.1007/978-3-642-27195-3 _2doi |
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| 050 | 4 | _aQD415-436 | |
| 072 | 7 |
_aPNN _2bicssc |
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| 072 | 7 |
_aSCI013040 _2bisacsh |
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| 082 | 0 | 4 |
_a547 _223 |
| 100 | 1 |
_aSun, Xiao-Yu. _eauthor. |
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| 245 | 1 | 0 |
_aTotal Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B _h[electronic resource] / _cby Xiao-Yu Sun. |
| 264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2012. |
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| 300 |
_aXIV, 220p. 308 illus., 12 illus. in color. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 490 | 1 | _aSpringer Theses | |
| 505 | 0 | _aIntroduction -- Results and Discussion -- Conclusion -- Experimental Section -- References -- Appendix I -- Appendix II. | |
| 520 | _aIn his thesis, Xiao-yu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiao-yu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery. | ||
| 650 | 0 | _aChemistry. | |
| 650 | 0 | _aChemistry, Organic. | |
| 650 | 0 | _aBiochemistry. | |
| 650 | 0 | _aCatalysis. | |
| 650 | 1 | 4 | _aChemistry. |
| 650 | 2 | 4 | _aOrganic Chemistry. |
| 650 | 2 | 4 | _aMedicinal Chemistry. |
| 650 | 2 | 4 | _aCatalysis. |
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9783642271946 |
| 830 | 0 | _aSpringer Theses | |
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-642-27195-3 |
| 912 | _aZDB-2-CMS | ||
| 999 |
_c102533 _d102533 |
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