000			03016nam a22004935i 4500
001			978-3-642-25135-1
003			DE-He213
005			20140220083305.0
007			cr nn 008mamaa
008			120103s2012 gw | s |||| 0|eng d
020			_a9783642251351 _9978-3-642-25135-1
024	7		_a10.1007/978-3-642-25135-1 _2doi
050		4	_aQD380-388
072		7	_aPNNP _2bicssc
072		7	_aTEC055000 _2bisacsh
082	0	4	_a541.2254 _223
100	1		_aJ.N.Junk, Matthias. _eauthor.
245	1	0	_aAssessing the Functional Structure of Molecular Transporters by EPR Spectroscopy _h[electronic resource] / _cby Matthias J.N.Junk.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2012.
300			_aXVI, 212p. 105 illus., 25 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aSpringer Theses
505	0		_aElectron Paramagnetic Resonance Theory -- The Functional Structure of Human Serum Albumin -- Copper Complexes of Star-Shaped Cholic Acid Oligomers with 1,2,3-Triazole Moieties -- Nano-Inhomogeneities in Structure and Reactivity  of Thermoresponsive Hydrogels -- Thermoresponsive Spin-Labeled Hydrogels as Separable DNP Polarizing Agents -- Local Nanoscopic Heterogeneities in Thermoresponsive Dendronized Polymers.
520			_aIn his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure – a consequence of the protein’s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material’s hosting properties and enable unforeseen complex catalytic functionalities.
650		0	_aChemistry.
650		0	_aSpectroscopy.
650		0	_aChemistry, Physical organic.
650		0	_aPolymers.
650	1	4	_aChemistry.
650	2	4	_aPolymer Sciences.
650	2	4	_aSpectroscopy/Spectrometry.
650	2	4	_aSoft and Granular Matter, Complex Fluids and Microfluidics.
650	2	4	_aPhysical Chemistry.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642251344
830		0	_aSpringer Theses
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-25135-1
912			_aZDB-2-CMS
999			_c102385 _d102385