000 03163nam a22004935i 4500
001 978-3-642-24989-1
003 DE-He213
005 20140220083304.0
007 cr nn 008mamaa
008 120109s2012 gw | s |||| 0|eng d
020 _a9783642249891
_9978-3-642-24989-1
024 7 _a10.1007/978-3-642-24989-1
_2doi
050 4 _aRB45
072 7 _aMJF
_2bicssc
072 7 _aMED038000
_2bisacsh
082 0 4 _a616.15
_223
100 1 _aBarbui, Tiziano.
_eeditor.
245 1 0 _aMyeloproliferative Neoplasms
_h[electronic resource] :
_bCritical Concepts and Management /
_cedited by Tiziano Barbui, Ayalew Tefferi.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2012.
300 _aVIII, 240p. 22 illus., 13 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aHematologic Malignancies
505 0 _aBiology -- Gerneral Issues in the Management of MPNs -- Specific Issues of Treatment in PV and ET -- Treatment of PMF -- Research Issues and Perspectives.
520 _aMyeloproliferative neoplasms (MPNs) are clonal stem cell diseases that, under the World Health Organization classification, are subcategorized into eight clinicopathologic entities. The current book focuses on three of these categories: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. A number of important questions regarding the diagnosis, prognosis, and treatment of these diseases have arisen following the discovery of the JAK2 V617F mutation in the majority of patients with bcr/abl-negative MPNs.   This book comprises evidence-based reviews and expert consensus results. It offers comprehensive coverage of relevant laboratory and clinical advances and places great emphasis on the practical issues that challenge physicians in their daily practice. The main topics considered thus include contemporary diagnostic  approaches, the value and limitations of mutation screening for diagnostic and  prognostic purposes, risk stratification in terms of both survival and other  disease complications such as leukemic transformation and thrombosis, and  modern therapeutic strategies, including conventional drugs, allogeneic stem cell  transplantation, and experimental drugs still under study. The reader will find Critical Concepts and Management Recommendations in Myeloproliferative Neoplasms to be an invaluable and up-to-date source of information from leading authorities in the field.
650 0 _aMedicine.
650 0 _aInternal medicine.
650 0 _aHematology.
650 0 _aOncology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aHematology.
650 2 4 _aInternal Medicine.
650 2 4 _aOncology.
700 1 _aTefferi, Ayalew.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642249884
830 0 _aHematologic Malignancies
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-24989-1
912 _aZDB-2-SME
999 _c102366
_d102366