000 03392nam a22004215i 4500
001 978-3-642-24294-6
003 DE-He213
005 20140220083303.0
007 cr nn 008mamaa
008 120913s2012 gw | s |||| 0|eng d
020 _a9783642242946
_9978-3-642-24294-6
024 7 _a10.1007/978-3-642-24294-6
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
100 1 _aRadtke, Freddy.
_eeditor.
245 1 0 _aNotch Regulation of the Immune System
_h[electronic resource] /
_cedited by Freddy Radtke.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2012.
300 _aXI, 184 p. 26 illus., 24 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v360
520 _aNotch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This volume of Current Topics in Microbiology and Immunology covers divers topics of Notch function within the immune system.  The review series starts with an overview on the role of Notch function for the generation, and specification of hematopoietic stem cells during mouse development and adulthood. Chapters follow describing molecular players and specific functions of Notch during T cell lineage commitment and maturation in both mouse and human. Once T cell development is accomplished and T cells have been positively and negatively selected, they migrate from the thymus to the periphery. There they regulate host defense to pathogens as well as immune homeostasis, which is described in two chapters of this series. A subsequent report summarizes recent findings suggesting a role of Notch in regulating alloreactive T cell immunity. This process mediates recognition of foreign antigens in recipients of organ transplants. The family of Notch receptors consists of four family members (Notch1-4). Some aspects of Notch function in immunity are regulated by single others by multiple receptors. One review of this series describes the specific function of Notch2 during hematopoietic lineage specification and immune function. The last chapter is dedicated to the oncogenic properties of NOTCH1 in T cell acute lymphoblastic leukemia (T-ALL) and potential avenues of targeting NOTCH1 therapeutically. Collectively these reviews summarize the pleiotropic functions of Notch in immunity and there is undoubtedly more to come in the future.
650 0 _aMedicine.
650 0 _aImmunology.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642242939
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v360
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-24294-6
912 _aZDB-2-SBL
999 _c102276
_d102276