000			03110nam a22005055i 4500
001			978-3-642-23988-5
003			DE-He213
005			20140220083302.0
007			cr nn 008mamaa
008			110929s2012 gw | s |||| 0|eng d
020			_a9783642239885 _9978-3-642-23988-5
024	7		_a10.1007/978-3-642-23988-5 _2doi
050		4	_aQH601-602
050		4	_aQR77
072		7	_aPHVN _2bicssc
072		7	_aPSF _2bicssc
072		7	_aSCI009000 _2bisacsh
082	0	4	_a571.64 _223
100	1		_aGuseva, Ksenia. _eauthor.
245	1	0	_aFormation and Cooperative Behaviour of Protein Complexes on the Cell Membrane _h[electronic resource] / _cby Ksenia Guseva.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2012.
300			_aXII, 80 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aSpringer Theses
505	0		_aIntroduction -- The Role of Fragmentation on the Formation of Homomeric Protein Complexes -- Collective Response of Self-organised Clusters of Mechanosensitive Channels -- Assembly and Fragmentation of Tat Pores -- Conclusion.
520			_aWith the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process.
650		0	_aPhysics.
650		0	_aPolymers.
650		0	_aCell membranes.
650	1	4	_aPhysics.
650	2	4	_aMembranes.
650	2	4	_aMembrane Biology.
650	2	4	_aStatistical Physics, Dynamical Systems and Complexity.
650	2	4	_aPolymer Sciences.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642239878
830		0	_aSpringer Theses
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-23988-5
912			_aZDB-2-PHA
999			_c102245 _d102245