000 03840nam a22004935i 4500
001 978-3-642-23690-7
003 DE-He213
005 20140220083302.0
007 cr nn 008mamaa
008 110913s2012 gw | s |||| 0|eng d
020 _a9783642236907
_9978-3-642-23690-7
024 7 _a10.1007/978-3-642-23690-7
_2doi
050 4 _aRM281
050 4 _aQR189-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a615.372
_223
100 1 _aTeunissen, Marcel B.M.
_eeditor.
245 1 0 _aIntradermal Immunization
_h[electronic resource] /
_cedited by Marcel B.M. Teunissen.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2012.
300 _aX, 254 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v351
505 0 _aPreface -- Understanding the murine cutaneous dendritic cell network to improve intradermal vaccination strategies -- Insight into the immunobiology of human skin and cutaneous dendritic cell subsets to perfection intradermal vaccination design -- Delivery systems for intradermal vaccination -- Targeting skin dendritic cells to improve intradermal immunization -- Intradermal Rabies vaccination: the evolution and future of pre- and post-exposure prophylaxis -- Intradermal vaccination to protect against yellow fever and influenza -- The dermis as a portal for dendritic cell-targeted immunotherapy of cutaneous melanoma -- DNA vaccines and intradermal vaccination by DNA tattooing -- Subject index.
520 _aDespite the impressive success of current vaccine programs, there remains a need to improve the effectiveness of current vaccines. A more powerful and longer lasting immune response induced by smaller and fewer doses of vaccine is an exciting challenge. Improvement of effectiveness also enables induction of protective immunity in populations that respond poorly to vaccination, for example elderly or immune-compromised individuals.  This volume of Current Topics in Microbiology and Immunology covers diverse topics related to intradermal immunization. The volume starts with a basic overview of murine and human skin dendritic cell network, respectively, and their role in immunity, as well as an extensive description of the immunobiology of the skin. The next chapter describes the state-of-the-art on delivery systems especially designed for intradermal vaccination. The remaining chapters highlight the effectiveness of intradermal immunization in experimental animal models or in clinical practice, all supporting the view that intradermal immunization is at least as good as other immunization routes. Keeping in mind that current vaccines are not specially designed for intradermal immunization, but show comparable efficiency even at reduced dosages, this underlines the great potential for the skin as a vaccination site Hopefully, the overview in this volume will encourage vaccine designers to focus on this promising immunization route, and in addition, to inspire them to develop vaccines that are especially optimized for intradermal immunization.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aVaccines.
650 0 _aDermatology.
650 1 4 _aBiomedicine.
650 2 4 _aVaccine.
650 2 4 _aImmunology.
650 2 4 _aDermatology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642236891
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v351
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-23690-7
912 _aZDB-2-SBL
999 _c102211
_d102211