000			03943nam a22004575i 4500
001			978-3-642-22964-0
003			DE-He213
005			20140220083300.0
007			cr nn 008mamaa
008			120113s2012 gw | s |||| 0|eng d
020			_a9783642229640 _9978-3-642-22964-0
024	7		_a10.1007/978-3-642-22964-0 _2doi
050		4	_aRJ1-570
072		7	_aMJW _2bicssc
072		7	_aMED069000 _2bisacsh
082	0	4	_a618.92 _223
100	1		_aHutson, John M. _eeditor.
245	1	0	_aDisorders of Sex Development _h[electronic resource] : _bAn Integrated Approach to Management / _cedited by John M. Hutson, Garry L. Warne, Sonia R. Grover.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2012.
300			_aXV, 311p. 138 illus., 57 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aThe molecular basis of gonadal development and disorders of sex development -- Embryology of the human genital tract -- The hormones regulating sex development -- Questions about gender – children with atypical gender development -- Abnormal embryology in DSD -- 46XX Disorders of Sex Development -- 46,XY DSD -- Mixed Sex chromosome (aneuploidy) and ovo-testicular DSD -- Non-hormone DSD -- Multiple malformation syndromes in DSD -- The neonatate with ambiguous genitalia -- DSD later in childhood -- The adolescent or young adult with DSD -- Imaging in DSD -- Ethical principles for the management of infants with DSD. The medical management of DSD -- Surgical treatment in infancy -- Laparoscopy for DSD -- The family -- Genetic Counselling -- Cultural differences and controversies about timing of management -- Medical management of adolescents and young adults -- Gynaecological management -- Psychological Management in Adolescence and Beyond -- Short, medium and long-term outcomes following  surgery for DSD at Royal Children’s Hospital -- Long-term outcome of DSD: a world view -- Complete Androgen Insensitivity Syndrome (A guide for parents and patients).
520			_aThe birth of a baby with ambiguous genitalia triggers a chain reaction of difficulties that rapidly spread to the entire family and most medical attendants, leading to lasting effects on the gender identity, personality, and sexual functioning of the unfortunate individual.  The rapid advances in medicine over the last 50 years have totally changed the outlook for children with disorders of sex development (DSD), but there is still much to learn.   This book crystallizes the combined experience of a leading dedicated unit over 25 years in delivering expert medical and surgical care to children with DSD in a holistic environment.  It documents the most recent advances in the molecular biology and embryology of sex development, and describes each disorder in detail.  The clinical presentation and approach to diagnosis are described both for babies and for children presenting later in childhood or at adolescence.  The chapters on management highlight all the latest knowledge and include the shared wisdom of the authors on current controversies, such as the timing of surgical treatment.  Finally, the authors describe their short-, medium-, and long-term outcomes, which demonstrate the strengths of holistic team management.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aPediatrics.
650	1	4	_aMedicine & Public Health.
650	2	4	_aPediatrics.
650	2	4	_aHuman Genetics.
700	1		_aWarne, Garry L. _eeditor.
700	1		_aGrover, Sonia R. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642229633
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-22964-0
912			_aZDB-2-SME
999			_c102106 _d102106