000 04272nam a22005415i 4500
001 978-3-642-22916-9
003 DE-He213
005 20140220083300.0
007 cr nn 008mamaa
008 120105s2012 gw | s |||| 0|eng d
020 _a9783642229169
_9978-3-642-22916-9
024 7 _a10.1007/978-3-642-22916-9
_2doi
050 4 _aQH573-671
072 7 _aPSF
_2bicssc
072 7 _aSCI049000
_2bisacsh
082 0 4 _a571.6
_223
100 1 _aPérez Martín, José.
_eeditor.
245 1 0 _aMorphogenesis and Pathogenicity in Fungi
_h[electronic resource] /
_cedited by José Pérez Martín, Antonio Di Pietro.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2012.
300 _aXIII, 286p. 42 illus., 28 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aTopics in Current Genetics,
_x1610-2096 ;
_v22
505 0 _aMolecular basis of morphogenesis in fungi -- Tropic orientation responses of pathogenic fungi -- Hyphal fusion -- Signalling of infectious growth in Fusarium oxysporum -- Integrating Cdk signaling in Candida albicans environmental sensing networks -- Cell cycle and morphogenesis connections during the formation of the infective filament in Ustilago maydis -- Appressorium Function in Colletotrichum orbiculare and Prospect for Genome Based Analysis -- Morphogenesis in Candida albicans: How to stay focused -- Morphogenesis in Paracoccidioides brasiliensi -- Morphogenesis of Cryptococcus neoformans -- Morphogenesis and infection in Botrytis cinere.-  Morphogenesis, growth and development of the grass symbiont Epichlöe festucae -- Cryptococcus-neutrophil interaction.-.
520 _aInfectious fungal diseases continue to take their toll in terms of human suffering and enormous economic losses. Invasive infections by opportunistic fungal pathogens are a major cause of morbidity and mortality in immuno-compromised individuals. At the same time, plant pathogenic fungi have devastating effects on crop production and human health. New strategies for antifungal control are required to meet the challenges posed by these agents, and such approaches can only be developed through the identification of novel biochemical and molecular targets. However, in contrast to bacterial pathogens, fungi display a wealth of “lifestyles” and modes of infection. This diversity makes it extremely difficult to identify individual, evolutionarily conserved virulence determinants and represents a major stumbling block in the search for common antifungal targets. In order to activate the infection programme, all fungal pathogens must undergo appropriate developmental transitions that involve cellular differentiation and the introduction of a new morphogenetic programme. How growth, cell cycle progression and morphogenesis are co-ordinately regulated during development has been an active area of research in fungal model systems such as budding and fission yeast. By contrast, we have only limited knowledge of how these developmental processes shape fungal pathogenicity, or of the role of the cell cycle and morphogenesis regulators as true virulence factors. This book combines state-of-the-art expertise from diverse pathogen model systems to update our current understanding of the regulation of fungal morphogenesis as a key determinant of pathogenicity in fungi.  
650 0 _aLife sciences.
650 0 _aMicrobiology.
650 0 _aBiochemistry.
650 0 _aCytology.
650 0 _aDevelopmental biology.
650 0 _aEntomology.
650 1 4 _aLife Sciences.
650 2 4 _aCell Biology.
650 2 4 _aBiochemistry, general.
650 2 4 _aFungus Genetics.
650 2 4 _aDevelopmental Biology.
650 2 4 _aMedical Microbiology.
700 1 _aDi Pietro, Antonio.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642229152
830 0 _aTopics in Current Genetics,
_x1610-2096 ;
_v22
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-22916-9
912 _aZDB-2-SBL
999 _c102102
_d102102