000			02309nam a22004575i 4500
001			978-3-642-22801-8
003			DE-He213
005			20140220083300.0
007			cr nn 008mamaa
008			111104s2012 gw | s |||| 0|eng d
020			_a9783642228018 _9978-3-642-22801-8
024	7		_a10.1007/978-3-642-22801-8 _2doi
050		4	_aQH506
072		7	_aMBGR _2bicssc
072		7	_aPSD _2bicssc
072		7	_aSCI049000 _2bisacsh
072		7	_aMED067000 _2bisacsh
082	0	4	_a611.01816 _223
100	1		_aSamuel, Charles E. _eeditor.
245	1	0	_aAdenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing _h[electronic resource] / _cedited by Charles E. Samuel.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2012.
300			_aX, 238 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v353
520			_aThe objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected.  It also is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins.
650		0	_aMedicine.
650		0	_aHuman physiology.
650	1	4	_aBiomedicine.
650	2	4	_aMolecular Medicine.
650	2	4	_aHuman Physiology.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642228001
830		0	_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v353
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-22801-8
912			_aZDB-2-SBL
999			_c102089 _d102089