000 03198nam a22004815i 4500
001 978-3-642-22772-1
003 DE-He213
005 20140220083300.0
007 cr nn 008mamaa
008 111004s2012 gw | s |||| 0|eng d
020 _a9783642227721
_9978-3-642-22772-1
024 7 _a10.1007/978-3-642-22772-1
_2doi
050 4 _aQP34-38
072 7 _aMFG
_2bicssc
072 7 _aMED075000
_2bisacsh
082 0 4 _a612
_223
100 1 _aBrouns, Inge.
_eauthor.
245 1 0 _aNovel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors
_h[electronic resource] /
_cby Inge Brouns, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2012.
300 _aXII, 118p. 23 illus., 21 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Anatomy, Embryology and Cell Biology,
_x0301-5556 ;
_v211
520 _aAirway sensory nerve terminals are tailored to detect changes in the physical and chemical environment, thereby supplying local pulmonary information to the central nervous system. Since most intrapulmonary nerve terminals arise from fibres travelling in the vagal nerve, the classification of ‘sensory airway receptors’ is largely based on their action potential characteristics, electrophysiologically registered from the vagal nerve. However, the architecture of airways and lungs makes it nearly impossible to functionally locate the exact nerve terminals that are responsible for the transduction of a particular intrapulmonary stimulus. In this monograph we focus on three sensory receptor end organs in lungs that are currently morphologically well-characterised: smooth muscle-associated airway receptors (SMARs), neuroepithelial bodies (NEBs) and visceral pleura receptors (VPRs). Unravelling the main functional morphological and neurochemical characteristics of these sensory receptors using advanced immunohistochemistry and confocal microscopy has already allowed us to draw important conclusions about their potential function(s). The current development of ex vivo lung models for the selective identification of SMARs, NEBs and VPRs using vital staining will certainly facilitate direct physiological studies of these morphologically well-characterised airway receptors, since these models allow direct live studies of their functional properties.
650 0 _aMedicine.
650 0 _aHuman physiology.
650 0 _aNeurochemistry.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Physiology.
650 2 4 _aNeurochemistry.
700 1 _aPintelon, Isabel.
_eauthor.
700 1 _aTimmermans, Jean-Pierre.
_eauthor.
700 1 _aAdriaensen, Dirk.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642227714
830 0 _aAdvances in Anatomy, Embryology and Cell Biology,
_x0301-5556 ;
_v211
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-22772-1
912 _aZDB-2-SME
999 _c102084
_d102084