000			03741nam a22005535i 4500
001			978-3-642-21649-7
003			DE-He213
005			20140220083258.0
007			cr nn 008mamaa
008			111018s2012 gw | s |||| 0|eng d
020			_a9783642216497 _9978-3-642-21649-7
024	7		_a10.1007/978-3-642-21649-7 _2doi
050		4	_aQH573-671
072		7	_aPSF _2bicssc
072		7	_aSCI049000 _2bisacsh
082	0	4	_a571.6 _223
100	1		_aDenman, Robert B. _eeditor.
245	1	0	_aModeling Fragile X Syndrome _h[electronic resource] / _cedited by Robert B. Denman.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2012.
300			_aXII, 392 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aResults and Problems in Cell Differentiation, _x0080-1844 ; _v54
505	0		_aIntroduction: Reminiscing on Models and Modeling -- Probing Astrocyte Function in Fragile X Syndrome -- Neural Stem Cells -- Fragile X Mental Retardation Protein (FMRP) and the Spinal Sensory System -- The role of the postsynaptic density in the pathology of the fragile X syndrome -- Behavior in a Drosophila model of Fragile X -- Molecular and Genetic Analysis of the Drosophila Model of Fragile X Syndrome -- Fragile X Mental Retardation Protein and Stem Cells -- Manipulating the Fragile Mental Retardation Proteins in the frog -- Exploring the zebra finch Taeniopygia guttata as a novel animal model for the speech-language deficit of fragile X syndrome -- Neuroendocrine alterations in the fragile X mouse -- Taking STEPs forward to understanding Fragile X Syndrome -- Fmr-1 as an offspring genetic and a maternal environmental factor in neurodevelopmental disease -- Mouse Models of the Fragile X Premutation and the Fragile X Associated Tremor/Ataxia Syndrome -- Clinical Aspects of the Fragile X Syndrome -- Fragile X Syndrome: A Psychiatric Perspective -- Fragile X Syndrome and Targeted Treatment Trials -- The Fragile X-associated Tremor Ataxia Syndrome -- Vignettes: Models in Absentia.
520			_aThe present book is an in-depth synopsis of recent advances in the fragile X field. The fragile X syndrome (FXS) is the most common form of inherited mental retardation, and the molecular-genetic basis of this syndrome has been the subject of extensive experimental scrutiny over the last two decades. This book covers the spectrum of current FXS research, ranging from Drosophila model systems via mouse models to clinical and psychiatric aspects. The volume also provides updates on FXS-related diseases such as the fragile X-associated tremor/ataxia syndrome. Significant progress in recent years, as highlighted here by some of the most eminent researchers in the field, are grounds for optimism that successful therapeutical approaches may be feasible in the not too distant future.
650		0	_aLife sciences.
650		0	_aHuman genetics.
650		0	_aGene therapy.
650		0	_aMedicine.
650		0	_aCytology.
650		0	_aStem cells.
650		0	_aNeurobiology.
650	1	4	_aLife Sciences.
650	2	4	_aCell Biology.
650	2	4	_aHuman Genetics.
650	2	4	_aMolecular Medicine.
650	2	4	_aNeurobiology.
650	2	4	_aStem Cells.
650	2	4	_aGene Therapy.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642216480
830		0	_aResults and Problems in Cell Differentiation, _x0080-1844 ; _v54
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-21649-7
912			_aZDB-2-SBL
999			_c101995 _d101995