000 03011nam a22004335i 4500
001 978-3-0348-0364-9
003 DE-He213
005 20140220083254.0
007 cr nn 008mamaa
008 120404s2012 sz | s |||| 0|eng d
020 _a9783034803649
_9978-3-0348-0364-9
024 7 _a10.1007/978-3-0348-0364-9
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
100 1 _aGupta, Satya Prakash.
_eeditor.
245 1 0 _aMatrix Metalloproteinase Inhibitors
_h[electronic resource] :
_bSpecificity of Binding and Structure-Activity Relationships /
_cedited by Satya Prakash Gupta.
264 1 _aBasel :
_bSpringer Basel,
_c2012.
300 _aX, 285p. 184 illus., 11 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aExperientia Supplementum,
_x1023-294X ;
_v103
505 0 _aMatrix Metalloproteinases -- Specificity of Binding with Matrix Metalloproteinases -- The Gelatinases and Their Inhibitors: The Structure–Activity Relationships -- Advances in Studies on Collagenase Inhibitors -- Hydroxamic Acids as Matrix Metalloproteinase Inhibitors -- Quantitative Structure–Activity Relationship Studies on Sulfonamide-Based MMP Inhibitors -- Matrix Metalloproteinase Inhibitors as Investigative Tools in the Pathogenesis and Management of Vascular Disease.
520 _aMatrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases.   The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783034803632
830 0 _aExperientia Supplementum,
_x1023-294X ;
_v103
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-0348-0364-9
912 _aZDB-2-SBL
999 _c101732
_d101732