000			02919nam a22005535i 4500
001			978-3-0348-0218-5
003			DE-He213
005			20140220083253.0
007			cr nn 008mamaa
008			120104s2012 sz | s |||| 0|eng d
020			_a9783034802185 _9978-3-0348-0218-5
024	7		_a10.1007/978-3-0348-0218-5 _2doi
050		4	_aRM1-950
072		7	_aMMG _2bicssc
072		7	_aMED071000 _2bisacsh
082	0	4	_a615 _223
100	1		_aMolineux, Graham. _eeditor.
245	1	0	_aTwenty Years of G-CSF _h[electronic resource] : _bClinical and Nonclinical Discoveries / _cedited by Graham Molineux, MaryAnn Foote, Tara Arvedson.
264		1	_aBasel : _bSpringer Basel, _c2012.
300			_aXXII, 471p. 54 illus., 4 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aMilestones in Drug Therapy
505	0		_aBasic Science -- Use of rHuG-CSF in the Oncology Setting -- Use of rHuG-CSF in Non-Oncology Setting -- Safety and Economics -- The Next 20 Years.
520			_aGranulocyte colony-stimulating factor (G-CSF or GCSF) is a secreted glycoprotein that stimulates the proliferation and differentiation of granulocyte precursor cells, and induces mobilization of peripheral blood progenitor cells from the bone marrow. Development of recombinant human G-CSF has had a profound impact on the treatment of many diseases, including severe chronic neutropenia and cancer, and has enabled peripheral stem cell transplantation to supplant bone marrow transplantation in the autologous setting. This Milestones in Drug Therapy volume describes the experience of the last 20 years of treatment with recombinant human G-CSF, including the basic science, the use of recombinant human G-CSF in both the oncology and nononcology settings, and the safety and economics of its use. Many of the authors were the original investigators of recombinant human G-CSF and other authors are key researchers who provide their outlook for the next 20 years for use of and research with recombinant human G-CSF.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aImmunology.
650		0	_aToxicology.
650		0	_aHematology.
650		0	_aCytokines.
650	1	4	_aBiomedicine.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aCancer Research.
650	2	4	_aImmunology.
650	2	4	_aCytokines and Growth Factors.
650	2	4	_aHematology.
700	1		_aFoote, MaryAnn. _eeditor.
700	1		_aArvedson, Tara. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783034802178
830		0	_aMilestones in Drug Therapy
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-0348-0218-5
912			_aZDB-2-SBL
999			_c101716 _d101716