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001 978-3-0346-0480-2
003 DE-He213
005 20140220083253.0
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008 120104s2012 sz | s |||| 0|eng d
020 _a9783034604802
_9978-3-0346-0480-2
024 7 _a10.1007/978-3-0346-0480-2
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aStaines, Henry M.
_eeditor.
245 1 0 _aTreatment and Prevention of Malaria
_h[electronic resource] :
_bAntimalarial Drug Chemistry, Action and Use /
_cedited by Henry M. Staines, Sanjeev Krishna.
264 1 _aBasel :
_bSpringer Basel :
_bImprint: Springer,
_c2012.
300 _aX, 315p. 63 illus., 6 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMilestones in Drug Therapy
505 0 _aAntimalarial drugs and the control and elimination of malaria -- 4-Aminoquinolines: chloroquine, amodiaquine and next generation analogues -- Cinchona alkaloids: quinine and quinidine -- 8-Aminoquinolines: primaquine and tafenoquine -- Other 4-methanolquinolines, amyl alcohols and phentathrenes: mefloquine, lumefantrine, halofantrine, piperaquine and pyronaridine -- Antifolates: pyrimethamine, proguanil, sulphadoxine and dapsone -- Naphthoquinones: atovaquone, and other antimalarials targeting mitochondrial functions -- Non-antifolate antibiotics: clindamycin, doxycycline, azithromycin and fosmidomycin -- Artemisinins: artemisinin, dihydroartemisinin, artemether, arteether and artesunate -- Second generation peroxides: the OZs and artemisone -- Combination therapy in light of emerging artemisinin resistance -- New medicines to combat malaria: an overview of the global pipeline of therapeutics -- Molecular markers of Plasmodium resistance to antimalarials -- Prevention of malaria -- Malaria diagnostics: lighting the path.
520 _aMalaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions.   Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aDrug interactions.
650 0 _aMedical parasitology.
650 0 _aToxicology.
650 0 _aEmerging infectious diseases.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aInfectious Diseases.
650 2 4 _aParasitology.
650 2 4 _aImmunology.
650 2 4 _aDrug Resistance.
700 1 _aKrishna, Sanjeev.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783034604796
830 0 _aMilestones in Drug Therapy
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-0346-0480-2
912 _aZDB-2-SBL
999 _c101703
_d101703