000			02901nam a22004575i 4500
001			978-3-0346-0219-8
003			DE-He213
005			20140220083253.0
007			cr nn 008mamaa
008			120214s2012 sz | s |||| 0|eng d
020			_a9783034602198 _9978-3-0346-0219-8
024	7		_a10.1007/978-3-0346-0219-8 _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aThiel, Andreas. _eeditor.
245	1	0	_aImmunosenescence _h[electronic resource] / _cedited by Andreas Thiel.
264		1	_aBasel : _bSpringer Basel : _bImprint: Springer, _c2012.
300			_aXVIII, 235p. 4 illus., 2 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aBirkhäuser Advances in Infectious Diseases
505	0		_aRegulation of Adaptive Immunity in the Elderly -- Does Innate Immunity Get Old? -- Thy(-Im)Munosenescence: The Ageing of the Thymus and Its Impact on the Immune System -- Characteristics of B Cells and B Cell Responses in Aged Individuals -- Mechanisms of Immune Protection to Pneumococcal Infection in the Young and the Elderly -- CMV Subversion of the Immune System in Later Life -- Aging and Autoimmunity -- Vaccination in the Elderly -- Immunosenescence and the 3r’s; Restoration, Replacement and Reprogramming -- Novel Strategies of Improved Vaccines for Elderly: The Example of Influenza.
520			_aAs individuals age, their ability to respond to and clear pathogens and to control unwanted immune reactions declines, leading to a greater incidence of certain infectious diseases, autoimmunity and general immune dysfunctions. Most remarkably, the efficacy of vaccines is frequently decreased in elderly persons. Therefore, age-associated dysfunctions of the humoral and cellular immune responses have a strong clinical impact. Improving our understanding of the aged immune system is crucial in developing effective prevention and treatment programs that will facilitate healthy aging and improve the quality of life of the elderly population. The aim of this volume is to summarize current knowledge on the cellular and molecular aspects of the aging immune system, with an emphasis on infectious diseases and new therapeutic approaches.
650		0	_aMedicine.
650		0	_aImmunology.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aImmunology.
650	2	4	_aMolecular Medicine.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783034602181
830		0	_aBirkhäuser Advances in Infectious Diseases
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-0346-0219-8
912			_aZDB-2-SBL
999			_c101702 _d101702