000 04294nam a22004815i 4500
001 978-1-61779-812-2
003 DE-He213
005 20140220083252.0
007 cr nn 008mamaa
008 120604s2012 xxu| s |||| 0|eng d
020 _a9781617798122
_9978-1-61779-812-2
024 7 _a10.1007/978-1-61779-812-2
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aDietert, Rodney R.
_eeditor.
245 1 0 _aImmunotoxicity, Immune Dysfunction, and Chronic Disease
_h[electronic resource] /
_cedited by Rodney R. Dietert, Robert W. Luebke.
264 1 _aTotowa, NJ :
_bHumana Press :
_bImprint: Humana Press,
_c2012.
300 _aXV, 451 p. 19 illus., 10 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMolecular and Integrative Toxicology,
_x2168-4219
505 0 _aIntroduction to Immunotoxicity -- The Environment-Immune Route to Chronic Disease -- Asthma and Respiratory Allergies -- Cutaneous Allergies -- Food Allergies -- Factors Involved in Onset of Type1 Diabetes -- Rheumatoid Arthritis -- Environment, Immune Dysfunction and Systemic Lupus Erythematosus -- Multiple Sclerosis, Alzheimer’s Disease and Inflammation: A  Hypothetical View -- Immune Dysfunction in Autism Spectrum Disorders -- Atherosclerosis and Inflammatory Heart Disease -- Inflammatory Bowel Disease and Celiac Disease: Environmental Risks Factors and Consequences -- COPD and Other Inflammatory Diseases of the Lung:  Focus on AhR signaling -- Environment, the Immune System, and Depression: An Integrative Review and Discussion of the Infection-Defense Hypothesis -- Cancer – Childhood Acute Leukemia -- Environmental Toxicants and Susceptibility to Infection -- Reducing the Prevalence of Immune-Based Chronic Disease.
520 _aImmunotoxicity, Immune Dysfunction, and Chronic Disease is among the first books to illustrate the linkage between environmental risk factors (e.g., chemicals, drugs, diet, lifestyles), environmentally-induced immune dysfunction and the full range of resulting chronic diseases and conditions. There is a detailed discussion of specific immune-based chronic diseases and conditions that emerge in children and adults and affect different physiological systems. The book integrates a consideration of risk factors and specific immunotoxic alterations with disease outcomes. A significant number of diseases and conditions are discussed, such as systemic allergic diseases affecting the lung, skin and gastrointestinal tract, systemic autoimmune diseases (type 1 diabetes,multiple sclerosis and lupus) and chronic conditions that are not traditionally associated with chemically-mediated immunomodulation (depression, frailty, and atherosclerosis). Inflammatory dysregulation is a common thread that connects many of the diseases and conditions discussed in this book and provides a central focus.  Individual chapters are organized by disease with the addition of chapters that provide integrative information on: 1) patterns of disease comorbidities and 2) the safety testing of chemicals and drugs to reduce the risk of immune dysfunction.  Each chapter contains a summary of key points as well as recommendations when appropriate. The book stresses the benefits of identifying the environmental risk factors of immune-mediated chronic disease and the potential to reduce the prevalence of these diseases and conditions.  This volume is a valuable resource for researchers, clinicians, risk assessors and regulators and students.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aToxicology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aImmunology.
650 2 4 _aMolecular Medicine.
700 1 _aLuebke, Robert W.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781617798115
830 0 _aMolecular and Integrative Toxicology,
_x2168-4219
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-61779-812-2
912 _aZDB-2-SBL
999 _c101619
_d101619