000			03428nam a22004935i 4500
001			978-1-61779-788-0
003			DE-He213
005			20140220083252.0
007			cr nn 008mamaa
008			120420s2012 xxu| s |||| 0|eng d
020			_a9781617797880 _9978-1-61779-788-0
024	7		_a10.1007/978-1-61779-788-0 _2doi
050		4	_aQH573-671
072		7	_aPSF _2bicssc
072		7	_aSCI049000 _2bisacsh
082	0	4	_a571.6 _223
100	1		_aKavallaris, Maria. _eeditor.
245	1	0	_aCytoskeleton and Human Disease _h[electronic resource] / _cedited by Maria Kavallaris.
264		1	_aTotowa, NJ : _bHumana Press : _bImprint: Humana Press, _c2012.
300			_aXXIV, 453p. 63 illus., 42 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aActin -- Microtubules -- The Kinesin Superfamily -- Myosins -- The Actin Cytoskeleton and Membrane Organisation in T Lymphocytes -- Thin Filament Disease of Stricted Muscle -- Filamin and disease -- LIMK and Cancer Metastasis -- Actin Mutations and Deafness -- Therapeutic Targeting of the Actin Cytoskeleton -- Microtubules as a Target in Cancer Therapy -- Microtubules and drug resistance -- Posttranslational Modifications of Tubulin -- Stathmin and Cancer -- The Biology and Pathobiology of Tau Protein -- Tubulin-Related Malformations of Cortical Development -- Spectrins in Human Diseases -- Laminopathies -- Desmin and Heart Disease -- Neurodegenerative Diseases and Intermediate Filaments.
520			_aThe cytoskeleton is made up of a large variety of specialized proteins and is a highly dynamic system that is involved in the majority of key cellular events. It is now clear that the cytoskeleton is often associated, and has diverse roles in human disease.  Emerging understanding of the molecular and cellular events that drive cytoskeletal mediated disease including cancer, heart disease, myopathies, neurodegenerative diseases and skin disorders, are also helping shape targeted therapeutic approaches to treat these diseases.   Cytoskeleton and Human Disease Book Summary reviews the key components, mechanisms and clinical implications of cytoskeletal defects in disease. Contributed by leading investigators in their respective fields, the chapters include topics associated with the basics of the cytoskeleton, actin-associated disease states, microtubule-associated disease states and intermediate filament-associated disease states.   This authoritative volume is intended for a wide audience of clinicians, researchers and students with an interest in the application of biomedical research to the understanding and management of disease states associated with the cytoskeleton.
650		0	_aLife sciences.
650		0	_aOncology.
650		0	_aBiochemistry.
650		0	_aCytology.
650		0	_aCell cycle.
650	1	4	_aLife Sciences.
650	2	4	_aCell Biology.
650	2	4	_aCell Cycle Analysis.
650	2	4	_aCell Physiology.
650	2	4	_aBiochemistry, general.
650	2	4	_aCancer Research.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781617797873
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-61779-788-0
912			_aZDB-2-SBL
999			_c101617 _d101617